DO FISH LYMPHOCYTES SECRETE INTERFERON-GAMMA

被引：58

作者：

GRAHAM, S ^{[1
]}

SECOMBES, CJ ^{[1
]}

机构：

[1] UNIV ABERDEEN,DEPT ZOOL,TILLYDRONE AVE,ABERDEEN AB9 2TN,SCOTLAND

来源：

JOURNAL OF FISH BIOLOGY | 1990年 / 36卷 / 04期

关键词：

interferon‐γ; lymphocytes; MAF; rainbow trout;

D O I：

10.1111/j.1095-8649.1990.tb03557.x

中图分类号：

S9 [水产、渔业];

学科分类号：

0908 ;

摘要：

Macrophage activating factor (MAF)‐containing supernatants, generated by mitogen (Con A/PMA) stimulation of rainbow trout leucocytes, were found to confer viral resistance (interferon, IFN, activity) on a rainbow trout epithelial cell line challenged with infectious pancreatic necrosis virus. Both the MAF and IFN activities co‐eluted by HPLC size exclusion chromatography and showed similar sensitivities to acid (pH 2), temperature (60° C) and trypsin. The mode of induction of this IFN, its acid and temperature sensitivity and its possible MAF activity suggest that fish leucocytes can secrete an IFN‐γ like molecule. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：563 / 573

页数：11

共 34 条

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