TRANSLOCATION (14-19)(Q32-Q13.1) IN A YOUNG PATIENT WHO DEVELOPED A LARGE CELL LYMPHOMA AFTER AN INITIAL DIAGNOSIS OF CLL

被引：7

作者：

BUSSCHOTS, AM ^{[1
]}

MECUCCI, C ^{[1
]}

STUL, M ^{[1
]}

VANDENBERGHE, E ^{[1
]}

MICHAUX, JL ^{[1
]}

NOEL, H ^{[1
]}

CASSIMAN, JJ ^{[1
]}

VANDENBERGHE, H ^{[1
]}

机构：

[1] CATHOLIC UNIV LEUVEN,CTR HUMAN GENET,HEREST 49,B-3000 LOUVAIN,BELGIUM

来源：

LEUKEMIA & LYMPHOMA | 1991年 / 5卷 / 04期

关键词：

CLL; NHL; 14-19; TRANSLOCATION; LARGE CELL LYMPHOMA;

D O I：

10.3109/10428199109068138

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A translocation (14;19)(q32;q13.1) was found in a 31 year old man with a large cell lymphoma which had evolved from chronic lymphocytic leukaemia (CLL). Molecular analysis showed a monoclonal proliferation of B cells with rearrangement of the immunoglobulin (Ig) heavy and kappa light chain genes, and of the bcl-3 gene on chromosome 19q. Nine cases with t(14;19) from the literature were reviewed; B cell lymphoma had been diagnosed in eight and acute biphenotypic leukaemia in one of these cases. Four had transformed from CLL to a more aggressive disease, as in the present case. Two out of seven patients as well as the present one, with t(14;19) and CLL were young (less than 40). The t(14;19) is usually associated with other cytogenetic abnormalities; in our case a (15;16)(q15;p13) translocation was found and appears to be an additional nonrandom aberration in t(14;19) disorders. © 1991 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：281 / 286

页数：6

共 28 条

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