BIOSYNTHESIS OF ANATOXIN-A(S) - ORIGIN OF THE CARBONS

被引：21

作者：

MOORE, BS

OHTANI, I

DEKONING, CB

MOORE, RE

CARMICHAEL, WW

机构：

[1] UNIV HAWAII,DEPT CHEM,HONOLULU,HI 96822

[2] WRIGHT STATE UNIV,DEPT BIOL SCI,DAYTON,OH 45435

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 44期

关键词：

D O I：

10.1016/S0040-4039(00)60994-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

C-2, C-4, C-5 and C-6 of the potent anticholinesterase, anatoxin-a(s), in Anabaena flosaquae NRC 525-17 are derived from the guanido carbon, C-5, C-4 and C-3 of L-arginine, respectively, and the three O,N-methyl groups originate from the tetrahydrofolate C1 pool. Erythro-4-Hydroxy-L-arginine, a minor constituent of the cyanophyte, may be a precursor in the biosynthesis.

引用

页码：6595 / 6598

页数：4

共 11 条

[1]

COOK WO, 1989, ENVIRON TOXICOL CHEM, V8, P915, DOI [10.1897/1552-8618(1989)8[915:CIOPCB]2.0.CO

[2]

2, 10.1002/etc.5620081010]

[3] COMPARISON OF EFFECTS OF ANATOXIN-A(S) AND PARAOXON, PHYSOSTIGMINE AND PYRIDOSTIGMINE ON MOUSE-BRAIN CHOLINESTERASE ACTIVITY [J].