A UNIQUE INVIVO ASSESSMENT OF 4-[B-10]BORONO-L-PHENYLALANINE IN TUMOR-TISSUES FOR BORON NEUTRON-CAPTURE THERAPY OF MALIGNANT MELANOMAS USING POSITRON EMISSION TOMOGRAPHY AND 4-BORONO-2-[F-18]FLUORO-L-PHENYLALANINE

被引：44

作者：

ISHIWATA, K

SHIONO, M

KUBOTA, K

YOSHINO, K

HATAZAWA, J

IDO, T

HONDA, C

ICHIHASHI, M

MISHIMA, Y

机构：

[1] Research Institute for Tuberculosis and Cancer, Tohoku University, Department of Dermatology, Sendai

[2] Tohoku University, Department Radiology and Nuclear Medicine

[3] Special Institute of Cancer Neutron Capture Therapy, Kobe University School of Medicine, Department of chemistry, Shinshu University, Matsumoto, Kobe

来源：

MELANOMA RESEARCH | 1992年 / 2卷 / 03期

关键词：

BORON NEUTRON CAPTURE THERAPY; BORONOFLUOROPHENYLALANINE; BORONOPHENYLALANINE; F-18; POSITRON EMISSION TOMOGRAPHY;

D O I：

10.1097/00008390-199209000-00005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A unique in vivo approach to assessing the concentrations of 4-[B-10]borono-L-phenylalanine (L-BPA), a melanoma targeting compound for boron neutron capture therapy (BNCT), was investigated using L-BPA labelled with positron-emitting F-18 (half-life = 110 min), i.e., 4-[B-10]borono-2-[F-18]fluoro-L-phenylalanine (L-[F-18]FBPA). High melanoma uptake of L-[F-18]FBPA was reduced slightly by competition with L-BPA in the two animal models of the murine B16 melanoma and the melanotic Greene's melanoma No. 179 in hamsters. In mice given L-[F-18]FBPA and L-BPA, the concentrations of B-10 in B16 estimated from F-18 radioactivity were lower than those measured by inductively coupled plasma-atomic emission spectroscopy. Lower estimated values were dependent on the time after injection and on the loading dose Of L-BPA. The estimated B-10 concentrations for Green's melanomas were comparable to the measured values. Positron emission tomography (PET) using L-[F-18]FBPA allowed Greene's melanomas to be clearly visualized. In conclusion, when L-[F-18]FBPA is used as a probe for L-BPA in BNCT of malignant melanomas, the melanoma can be localized and the B-10 concentrations in tissues can be assessed in vivo using F-18 radioactivity by PET.

引用

页码：171 / 179

页数：9

共 28 条

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