THE EFFECT OF CENTRAL BLOCKADE OF KAPPA-OPIOID RECEPTORS ON NEUROPEPTIDE Y-INDUCED FEEDING IN THE RAT

被引：25

作者：

LAMBERT, PD ^{[1
]}

WILDING, JPH ^{[1
]}

ALDOKHAYEL, AAM ^{[1
]}

GILBEY, SG ^{[1
]}

BLOOM, SR ^{[1
]}

机构：

[1] HAMMERSMITH HOSP,ROYAL POSTGRAD MED SCH,DIV ENDOCRINOL & METAB,DU CANE RD,LONDON W12 0NN,ENGLAND

来源：

BRAIN RESEARCH | 1993年 / 629卷 / 01期

关键词：

NEUROPEPTIDE-Y; NORBINALTORPHIMINE; FEEDING; INTRACEREBROVENTRICULAR; RAT;

D O I：

10.1016/0006-8993(93)90493-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Neuropeptide Y (NPY) and the endogenous kappa-opioid receptor ligand, dynorphin (dyn), stimulate feeding when injected centrally in the rat. Norbinaltorphimine (norBNI, 25 nmol) reduced the feeding response to NPY (2.4 nmol) by 67% (P < 0.02). An additive effect of dynorphin and NPY was seen on food intake (saline 0.8 +/- 0. 1, dyn 1.9 +/- 0.4, NPY 6.1 +/- 1.4, dyn and NPY 9.7 +/- 2.2). A component of NPY-induced feeding may be mediated by kappa-opioid neuronal systems.

引用

页码：146 / 148

页数：3

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