AN ENZYME-SCISSILE LINKER FOR SOLID-PHASE PEPTIDE-SYNTHESIS

被引：20

作者：

ELMORE, DT

GUTHRIE, DJS

WALLACE, AD

BATES, SRE

机构：

[1] QUEENS UNIV BELFAST,SCH BIOL & BIOCHEM,BELFAST BT9 BL,NORTH IRELAND

[2] IST RECH BIOL MOLEC,I-00040 POMEZIA,ITALY

[3] APPL BIOSYST LTD,WARRINGTON,CHESHIRE,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1992年 / 14期

关键词：

D O I：

10.1039/c39920001033

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We describe a new linker that contains a phosphodiester moiety for solid-phase peptide synthesis; after completion of the cycle of coupling and deprotection steps, the phosphodiester can be cleaved with phosphodiesterase.

引用

页码：1033 / 1034

页数：2

共 10 条

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[4] LLOYD-WILLIAMS P, 1991, Tetrahedron, V47, P9867, DOI 10.1016/S0040-4020(01)80724-9
[5] A NEW FLUORIDOLYZABLE ANCHORING LINKAGE FOR ORTHOGONAL SOLID-PHASE PEPTIDE-SYNTHESIS - PREPARATION AND PROPERTIES OF THE N-(3 OR 4)-[[[(4-HYDROXYMETHYL)-PHENOXY-TERT-BUTYLPHENYL]SILYL]PHENYL]PENTANEDIOIC ACID, MONOAMIDE (PBS) HANDLE
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[6] A NEW FLUORIDOLYZABLE ANCHORING LINKAGE FOR ORTHOGONAL SOLID-PHASE PEPTIDE-SYNTHESIS - DESIGN, PREPARATION, AND APPLICATION OF THE N-(3 OR 4)-[[4-(HYDROXYMETHYL)PHENOXY]-TERT-BUTYLPHENYLSILYL]PHENYL PENTANEDIOIC ACID MONOAMIDE (PBS) HANDLE
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[7] SOLID-PHASE PEPTIDE-SYNTHESIS - FLUORIDE-ION RELEASE OF PEPTIDE FROM THE RESIN
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BARRON, CA
BIELECKI, S
THOMAS, DW
[J]. TETRAHEDRON LETTERS, 1987, 28 (35) : 4105 - 4108
[8] THE CAMET AND CASET LINKS FOR THE SYNTHESIS OF PROTECTED OLIGOPEPTIDES AND OLIGODEOXYNUCLEOTIDES ON SOLID AND SOLUBLE SUPPORTS
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FELDER, E
FAILLI, P
[J]. HELVETICA CHIMICA ACTA, 1984, 67 (05) : 1316 - 1327
[9] TAM JP, 1980, INT J PEPT PROT RES, V16, P412
[10] FACILE REMOVAL OF A PEPTIDE-CHAIN FROM A SOLID-PHASE RESIN SUPPORT BY HYDROLYSIS USING TETRABUTYLAMMONIUM FLUORIDE TRIHYDRATE IN N,N-DIMETHYLFORMAMIDE
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