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P53 EXPRESSION IN ANAPLASTIC CARCINOMAS ARISING FROM THYROID PAPILLARY CARCINOMAS

被引：31
作者：
MATIASGUIU, X
CUATRECASAS, M
MUSULEN, E
PRAT, J
机构：
[1] Department of Pathology, Hospital de la Santa Creu i Sant Pau, 08025 Barcelona
来源：
JOURNAL OF CLINICAL PATHOLOGY | 1994年 / 47卷 / 04期
关键词：
D O I：
10.1136/jcp.47.4.337
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Aim-To study the expression of p53 tumour suppressor gene in anaplastic carcinomas arising from thyroid papillary carcinomas. Methods-Formalin fixed, paraffin wax embedded tissues from four cases of anaplastic carcinomas associated with thyroid papillary carcinomas were studied by immunohistochemistry with two different p53 monoclonal antibodies. Results-The anaplastic component showed nuclear immunostaining in two cases, but not in the other two. In all cases the papillary carcinoma component was negative. Conclusion-The results support the hypothesis that p53 stimulates tumour progression in thyroid tumours.
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收藏
页码：337 / 339
页数：3
相关论文
共 14 条
[1]  
BARTEK J, 1990, ONCOGENE, V5, P893
[2]  
CARR K, 1993, MODERN PATHOL, V6, pA37
[3]  
Crawford L V, 1984, Mol Biol Med, V2, P261
[4]   OVEREXPRESSION OF P53 AS A POSSIBLE PROGNOSTIC FACTOR IN HUMAN THYROID-CARCINOMA [J].
DOBASHI, Y ;
SAKAMOTO, A ;
SUGIMURA, H ;
MERNYEI, M ;
MORI, M ;
OYAMA, T ;
MACHINAMI, R .
AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 1993, 17 (04) :375-381
[5]   GENE P53 MUTATIONS ARE RESTRICTED TO POORLY DIFFERENTIATED AND UNDIFFERENTIATED CARCINOMAS OF THE THYROID-GLAND [J].
DONGHI, R ;
LONGONI, A ;
PILOTTI, S ;
MICHIELI, P ;
DELLAPORTA, G ;
PIEROTTI, MA .
JOURNAL OF CLINICAL INVESTIGATION, 1993, 91 (04) :1753-1760
[6]   HIGH PREVALENCE OF MUTATIONS OF THE P53 GENE IN POORLY DIFFERENTIATED HUMAN THYROID CARCINOMAS [J].
FAGIN, JA ;
MATSUO, K ;
KARMAKAR, A ;
CHEN, DL ;
TANG, SH ;
KOEFFLER, HP .
JOURNAL OF CLINICAL INVESTIGATION, 1993, 91 (01) :179-184
[7]   THE P53 PROTO-ONCOGENE CAN ACT AS A SUPPRESSOR OF TRANSFORMATION [J].
FINLAY, CA ;
HINDS, PW ;
LEVINE, AJ .
CELL, 1989, 57 (07) :1083-1093
[8]  
ITO T, 1992, CANCER RES, V52, P1369
[9]  
KUPRYJANCZYK J, 1993, MODERN PATHOL, V6, pA75
[10]   P53-GENE MUTATIONS ASSOCIATED WITH ANAPLASTIC TRANSFORMATION OF HUMAN THYROID CARCINOMAS [J].
NAKAMURA, T ;
YANA, I ;
KOBAYASHI, T ;
SHIN, E ;
KARAKAWA, K ;
FUJITA, S ;
MIYA, A ;
MORI, T ;
NISHISHO, I ;
TAKAI, S .
JAPANESE JOURNAL OF CANCER RESEARCH, 1992, 83 (12) :1293-1298
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