OPTICAL SENSORS FOR IN-VITRO BLOOD-GAS ANALYSIS

被引:25
作者
LEINER, MJP
机构
[1] AVL List GmbH, A-8020 Graz
关键词
OPTICAL SENSORS; BLOOD GAS ANALYSIS;
D O I
10.1016/0925-4005(95)01679-1
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Optical sensors for in vitro testing of blood samples have been developed. The sensors have been tested for single-shot blood gas and blood pH analysis. They work in combination with disposable plastic how-through cells, allowing calibrants and the sample to be introduced. Optic and electronic components include a tungsten-halogen lamp as the light source, photodiode detectors, interference and cut-off filters for wavelength selection and fiber optic pathways to illuminate the optodes and to return the fluorescence signals to photodiode detectors. The basic optode technology, design parameters and performance characteristics with human blood samples are presented. In the pH range 7.0-7.5 the pH optodes showed a precision of 0.014 (SD). Compared to the electrode readings, the average bias was 0.051 pH units. In the range 15-110 Torr the overall precision of the CO, optodes was 0.9 Torr (SD), and in the range 5-150 Torr the overall precision of the O-2 optodes was 0.9 Torr (SD). The results obtained are comparable to that of a state-of-the-art blood gas analyzer.
引用
收藏
页码:169 / 173
页数:5
相关论文
共 11 条
[1]  
BRIGGS WS, 1992, Patent No. 5144576
[2]  
HILL AG, 1985, P AM ACAD CARDIOVASC, V6, P148
[3]   LUMINESCENCE CHEMICAL SENSORS FOR BIOMEDICAL APPLICATIONS - SCOPE AND LIMITATIONS [J].
LEINER, MJP .
ANALYTICA CHIMICA ACTA, 1991, 255 (02) :209-222
[4]   THEORY AND PRACTICE IN OPTICAL PH SENSING [J].
LEINER, MJP ;
HARTMANN, P .
SENSORS AND ACTUATORS B-CHEMICAL, 1993, 11 (1-3) :281-289
[5]  
Leiner MJP, 1991, FIBER OPTIC CHEM SEN, V1, P359
[6]  
SHAPIRO BA, 1988, CRIT CARE MED, V21, P487
[7]  
SIGGAARDANDERSE.O, 1988, SCAND J CLIN LA S189, V48, P77
[8]   FLUORIMETRIC ANALYSIS .1. A STUDY ON FLUORESCENT INDICATORS FOR MEASURING NEAR NEUTRAL (PHYSIOLOGICAL) PH-VALUES [J].
WOLFBEIS, OS ;
FURLINGER, E ;
KRONEIS, H ;
MARSONER, H .
FRESENIUS ZEITSCHRIFT FUR ANALYTISCHE CHEMIE, 1983, 314 (02) :119-124
[9]  
WOLFBEIS OS, 1986, MIKROCHIM ACTA, V3, P359
[10]  
WOLFBEIS OS, 1991, FIBER OPTIC CHEM SEN, V2, P259