THE PROLIFERATIVE RESPONSE OF PERIPHERAL-BLOOD MONONUCLEAR-CELLS TO STREPTOKINASE - A STUDY OF PATIENTS RECEIVING A SINGLE INTRAVENOUS-INFUSION OF PURIFIED STREPTOKINASE

In vitro proliferative PBM responses were investigated for 26 patients with and 5 patients without acute myocardial infarction. All patients were initially treated with streptokinase (1.5 MIU infused for 1 hour). Five weeks after the disease increased responses to streptokinase, PPD and PHA were seen; but only for streptokinase had original nonresponders become responders (7 out of 14 nonresponders). The increased responsiveness to streptokinase could be detected five days after antigen infusion, and CD2-positive cells constituted a major part of the proliferating PBM population. The responses after antigen infusion varied within a wide range both for patients with and without myocardial infarction.