O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE ACTIVITY IN HUMAN BRAIN-TUMORS

被引：43

作者：

FROSINA, G

ROSSI, O

ARENA, G

GENTILE, SL

BRUZZONE, E

ABBONDANDOLO, A

机构：

[1] UNIV GENOA, CHAIR GENET, I-16126 GENOA, ITALY

[2] SAN MARTINO HOSP, NEUROSURG CLIN, GENOA, ITALY

来源：

CANCER LETTERS | 1990年 / 55卷 / 02期

关键词：

O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE; CHLOROETHYLNITROSOUREAS; BRAIN TUMORS; DRUG RESISTANCE; DNA REPAIR;

D O I：

10.1016/0304-3835(90)90026-T

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The O6-alkylguanine-DNA alkyltransferase (AT) activity in different kinds of human brain tumors was investigated. Twenty-seven brain tumors were analysed. Twenty-five of them showed proficient AT activity with values ranging between 20 and 722 fmol AT/mg protein. The two AT-deficient tumors observed were an oligodendroglioma and an astrocytoma. The relationship between the different histological kinds of tumor, with respect to the AT activity was: meningeomas > sarcomas > glioblastomas > astrocytomas > oligodendrogliomas > neurinomas > lymphomas. The proposal of Kohn (DNA filter elution methods in anticancer drug development. In: Concepts, Clinical Developments, and Therapeutic Advances in Cancer Chemotherapy. Editor: F.M. Muggia. Martinus Nijhoff Publishers, Boston) to confine treatments with alkylating antineoplastic agents to AT-deficient tumors, is discussed.

引用

页码：153 / 158

页数：6

共 21 条

[1]

ALIOSMAN F, 1989, CANCER RES, V49, P5258

[2] ISOLATION OF CLONES DISPLAYING ENHANCED RESISTANCE TO METHYLATING AGENTS IN O-6-METHYLGUANINE-DNA METHYLTRANSFERASE-PROFICIENT CHO CELLS [J].