RESPONSES OF REGIONAL CEREBRAL BLOOD-FLOW FOLLOWING FOCAL ELECTRICAL-STIMULATION OF THE NUCLEUS BASALIS OF MEYNERT AND THE MEDIAL SEPTUM USING THE [C-14] IODOANTIPYRINE METHOD IN RATS

被引：32

作者：

ADACHI, T ^{[1
]}

INANAMI, O ^{[1
]}

OHNO, K ^{[1
]}

SATO, A ^{[1
]}

机构：

[1] TOKYO METROPOLITAN GERIATR HOSP & INST GERONTOL,DEPT PHYSIOL,35-2 SAKAECHO,ITABASHI KU,TOKYO 173,JAPAN

来源：

NEUROSCIENCE LETTERS | 1990年 / 112卷 / 2-3期

基金：

日本科学技术振兴机构;

关键词：

Electrical stimulation; Medial septum; Nucleus basalis of Meynert; Rat; Regional cerebral blood flow; [!sup]14[!/sup]C]Iodoantipyrine;

D O I：

10.1016/0304-3940(90)90214-T

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of focal electrical stimulation of the nucleus basalis of Meynert (NBM) and the medial septum (MS) on regional cerebral blood flow (rCBF) of the 14 brain regions were examined in halothaneanesthetized rats using the [14C]iodoantipyrine (14]IAP) method. The stimulation of the unilateral NBM (with parameters of 200 μA, 0.5 ms, 50 Hz for 60 s) produced significant increases in frontal, parietal and occipital cortical blood flows in the hemisphere ipsilateral to the stimulated NBM; no rCBFs in all other brain regions examined were influenced by the stimulation. The stimulation of the MS produced significant increases in bilateral hippocampal rCBFs, but rCBFs in other brain regions were not influenced by the stimulation. In summary, the response of increase in rCBF following focal electrical stimulation of the NBM or MS is restricted to regions that receive cholinergic nerve projections from the NBM or MS. © 1990.

引用

页码：263 / 268

页数：6

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