EFFECT OF CALCITONIN ON TOTAL-BODY BONE-MINERAL CONTENTS OF EXPERIMENTAL OSTEOPOROTIC RATS DETERMINED BY DUAL PHOTON-ABSORPTIOMETRY

被引：13

作者：

NAKATSUKA, K ^{[1
]}

NISHIZAWA, Y ^{[1
]}

HAGIWARA, S ^{[1
]}

KOYAMA, H ^{[1
]}

MIKI, T ^{[1
]}

OCHI, H ^{[1
]}

MORII, H ^{[1
]}

机构：

[1] OSAKA CITY UNIV,SCH MED,DEPT RADIOL,OSAKA 545,JAPAN

来源：

CALCIFIED TISSUE INTERNATIONAL | 1990年 / 47卷 / 06期

关键词：

Ash weight; Bone mineral; Calcitonin; Dual photon absorptiometry; Rat;

D O I：

10.1007/BF02555890

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Total body bone mineral (TBBM) content in rats was measured by dual photon absorptiometry (DPA). TBBM showed significant increases over 4 weeks in control groups with significant bone loss over the same time in prednisolone-injected rats on low calcium feed. Daily injections of calcitonin significantly reduced loss of bone mass. Both prednisolone- and prednisolone-calcitonin-injected groups showed significantly elevated serum alkaline phosphatase with the prednisolone-calcitonin group also exhibiting elevated serum calcium and phosphate levels, confirming the impact of the experimental protocol. TBBM measured by DPA in all groups correlated well (r=0.928, P<0.001 n=20) with the total ash weight suggesting that the method reflects total skeletal mineral content in the small animal. TBBM measurement by DPA proves well-suited to monitoring bone mineral in a small animal experimental setting. © 1990 Springer-Verlag New York Inc.

引用

页码：378 / 382

页数：5

共 22 条

[1]

AGRAWAL R, 1981, CALCITONIN 1980, V540, P237

[2]

Briskin A I, 1976, Klin Med (Mosk), V54, P97

[3]

Briskin A I, 1976, Klin Med (Mosk), V54, P80

[4] EFFECT OF PREDNISOLONE UPON METABOLISM AND ACTION OF 25-HYDROXYVITAMIN-D3 AND 1,25-DIHYDROXYVITAMIN-D3 [J].

CARRE, M ;

AYIGBEDE, O ;

MIRAVET, L ;

RASMUSSEN, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1974, 71 (08) :2996-3000

[5]

CHESNEY RW, 1978, LANCET, V2, P1123

[6] LONG-TERM CALCITONIN THERAPY IN POSTMENOPAUSAL OSTEOPOROSIS [J].

GRUBER, HE ;

IVEY, JL ;

BAYLINK, DJ ;

MATTHEWS, M ;

NELP, WB ;

SISOM, K ;

CHESNUT, CH .

METABOLISM-CLINICAL AND EXPERIMENTAL, 1984, 33 (04) :295-303

[7]

HAGAMAN JR, 1981, CALCIFIED TISSUE INT, V33, P587

[8] EFFECT OF CORTISONE TREATMENT ON ACTIVE TRANSPORT OF CALCIUM BY SMALL INTESTINE [J].

KIMBERG, DV ;

BAERG, RD ;

GERSHON, E ;

GRAUDUSIUS, RT .

JOURNAL OF CLINICAL INVESTIGATION, 1971, 50 (06) :1309-+

[9] MEASUREMENT OF BONE-MINERAL CONTENT (BMC) OF THE LUMBAR SPINE .2. CORRELATION BETWEEN FOREARM BMC AND LUMBAR SPINE BMC [J].

KROLNER, B ;

NIELSEN, SP ;

LUND, B ;

SORENSEN, OH ;

UHRENHOLDT, A .

SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION, 1980, 40 (07) :665-670

[10]

LUKERT BP, 1982, ARCH PHYS MED REHAB, V63, P480

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