THE EFFECTS OF EXOGENOUS MELATONIN ON THE TOTAL SLEEP TIME AND DAYTIME ALERTNESS OF CHRONIC INSOMNIACS - A PRELIMINARY-STUDY

被引：97

作者：

MACFARLANE, JG ^{[1
]}

CLEGHORN, JM ^{[1
]}

BROWN, GM ^{[1
]}

STREINER, DL ^{[1
]}

机构：

[1] MCMASTER UNIV,FAC HLTH SCI,HAMILTON L8S 4L8,ONTARIO,CANADA

来源：

BIOLOGICAL PSYCHIATRY | 1991年 / 30卷 / 04期

关键词：

D O I：

10.1016/0006-3223(91)90293-U

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of exogenous, supraphysiologic doses of melatonin on the total sleep time and daytime alertness of patients with chronic insomnia was examined in a double blind, single crossover study. Melatonin (75 mg per os) or identical placebo was administered at 10 PM daily to 13 insomniac patients for 14 consecutive days. A significant increase in the subjective assessment of total sleep time and daytime alertness was demonstrated with melatonin but not with placebo. However, 7 of the 13 patients reported that the active treatment had no significant effect on subjective feelings of well-being.

引用

页码：371 / 376

页数：6

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