PROSTAGLANDIN E2-INDUCED INHIBITION OF THE INVITRO IMMUNE-RESPONSE BY SRBC-STIMULATED HUMAN-LYMPHOCYTES

被引：5

作者：

MISEFARI, A

VALENTI, A

CAVALLARO, A

SOFO, V

SANTARPIA, G

SALMERI, FM

TETI, DV

机构：

[1] Institute of General Pathology, University of Messina, Medical School, 98121, Messina

来源：

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY | 1991年 / 13卷 / 1-2期

关键词：

D O I：

10.3109/08923979109019698

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Exogenous PGE2 strongly inhibits the response of human lymphocyte cultures to SRBC. This effect is mediated through a T cell inhibition since non-T cells are not significantly affected. Indomethacin, which inhibits in this system lymphocyte endogenous PGE2 synthesis increases the in vitro immune response. The effect of indomethacin is overcame by exogenous PGE2. These data may be relevant for explaining the immunomodulatory role of PGE2 following antigen challenge.

引用

页码：169 / 181

页数：13

共 12 条

[1]

BOYUM A, 1968, SCAND J CLIN LAB INV, VS 21, P77

[2]

GRONOWICZ E, 1976, EUR J IMMUNOL, V6, P58

[3]

LAVIA MF, 1981, FED PROC, V40, P1157

[4] EFFECT OF PROSTAGLANDINS ON FC-IGG RECEPTORS OF HUMAN CIRCULATING LYMPHOCYTES-T AND LYMPHOCYTES-B [J].