IN-VITRO INHIBITION OF MYCOBACTERIA BY RWANDESE MEDICINAL-PLANTS

被引：30

作者：

VANPUYVELDE, L ^{[1
]}

NTAWUKILIYAYO, JD ^{[1
]}

PORTAELS, F ^{[1
]}

HAKIZAMUNGU, E ^{[1
]}

机构：

[1] INST RECH SCI & TECHNOL,CTR RECH PHARMACOPEE & MED TRADIT,BUTARE,RWANDA

来源：

PHYTOTHERAPY RESEARCH | 1994年 / 8卷 / 02期

关键词：

MYCOBACTERIA; ANTIMYCOBACTERIUM ACTIVITY; TUBERCULOSIS; RWANDESE MEDICINAL PLANTS;

D O I：

10.1002/ptr.2650080202

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 15 Rwandese medicinal plants used by traditional healers to treat pulmonary diseases were screened for anti-Mycobacterium tuberculosis activity. Three plant extracts showed activity at 1000 mug/mL: Bidens pilosa (leaves), Pentas longiflora (roots) and Tetradenia riparia (leaves). These plant extracts were studied further against several mycobacterial species: M. tuberculosis, M. avium complex, M. simiae and a new simiae like Mycobacterium species (SLM). None of the plant extracts showed activity against M. avium and SLM at 1000 mug/mL. M. simiae was sensitive to T. riparia and P. longiflora extracts (1000 mug/mL) and M. tuberculosis towards T. riparia (500 mug/mL) and B. pilosa (100 mug/mL). The active principle of T. riparia, 8(14), 15-sandaracopimaradiene-7alpha, 18-diol, was also evaluated for its antimycobacterial activity and the concentration required for inhibiting M. tuberculosis ranged from 25 mug/mL to 100 mug/mL. The extract of the leaves of T. riparia can be used as a differentiation test (at 1000 mug/mL in the medium) for M. simiae and SLM.

引用

页码：65 / 69

页数：5

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