COMPLETE NUCLEOTIDE-SEQUENCES AND THE CHARACTERISTICS OF 2 HEPATITIS-B VIRUS MUTANTS CAUSING SEROLOGICALLY NEGATIVE ACUTE OR CHRONIC HEPATITIS-B

被引:47
作者
UCHIDA, T
GOTOH, K
SHIKATA, T
机构
[1] Department of Pathology, Nihon University School of Medicine, Tokyo
关键词
MUTATION; SILENT INFECTION; HEPATITIS F; X GENE; X PROTEIN;
D O I
10.1002/jmv.1890450303
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Hepatitis B virus (HBV) DNA was amplified by the polymerase chain reaction from the sera of a patient with acute hepatitis and a patient with chronic hepatitis. Both patients were negative for serum hepatitis B surface antigen and hepatitis B core antibodies and had been previously diagnosed as non-A, non-B, non-C, non-D, non-E hepatitis. The nucleotide sequence revealed an 8-nucleotide deletion in the X-gene coding region creating a C-terminally truncated X protein, and probable mutation of the enhancer II/core promoter element. In addition, DR2 showed a T-to-C mutation at the extreme 5'-terminus. These mutations within the X-gene coding region must suppress replication and expression of HBV DNA, and this seems to be responsible for absence of serological markers despite the presence of HBV infection; (C) 1995 Wiley-Liss, Inc.
引用
收藏
页码:247 / 252
页数:6
相关论文
共 42 条
[2]   SEQUENCE AND GENE STRUCTURE OF THE HEPATITIS-E VIRUS ISOLATED FROM MYANMAR [J].
AYE, TT ;
UCHIDA, T ;
MA, XZ ;
IIDA, F ;
SHIKATA, T ;
ICHIKAWA, M ;
RIKIHISA, T ;
WIN, KM .
VIRUS GENES, 1993, 7 (01) :95-110
[3]   SUBTYPE AYW VARIANT OF HEPATITIS-B VIRUS - DNA PRIMARY STRUCTURE-ANALYSIS [J].
BICHKO, V ;
PUSHKO, P ;
DREILINA, D ;
PUMPEN, P ;
GREN, E .
FEBS LETTERS, 1985, 185 (01) :208-212
[4]   VACCINE-INDUCED ESCAPE MUTANT OF HEPATITIS-B VIRUS [J].
CARMAN, WF ;
ZANETTI, AR ;
KARAYIANNIS, P ;
WATERS, J ;
MANZILLO, G ;
TANZI, E ;
ZUCKERMAN, AJ ;
THOMAS, HC .
LANCET, 1990, 336 (8711) :325-329
[5]   SIGNALS REGULATING HEPATITIS-B SURFACE-ANTIGEN TRANSCRIPTION [J].
CATTANEO, R ;
WILL, H ;
HERNANDEZ, N ;
SCHALLER, H .
NATURE, 1983, 305 (5932) :336-338
[6]   GENETIC ORGANIZATION AND DIVERSITY OF THE HEPATITIS-C VIRUS [J].
CHOO, QL ;
RICHMAN, KH ;
HAN, JH ;
BERGER, K ;
LEE, C ;
DONG, C ;
GALLEGOS, C ;
COIT, D ;
MEDINASELBY, A ;
BARR, PJ ;
WEINER, AJ ;
BRADLEY, DW ;
KUO, G ;
HOUGHTON, M .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (06) :2451-2455
[7]   TRANSCRIPTIONAL ACTIVATION OF HOMOLOGOUS AND HETEROLOGOUS GENES BY THE HEPATITIS-B VIRUS X-GENE PRODUCT IN CELLS PERMISSIVE FOR VIRAL REPLICATION [J].
COLGROVE, R ;
SIMON, G ;
GANEM, D .
JOURNAL OF VIROLOGY, 1989, 63 (09) :4019-4026
[8]   FUNCTIONAL-ORGANIZATION OF THE HEPATITIS-B VIRUS ENHANCER [J].
DIKSTEIN, R ;
FAKTOR, O ;
BENLEVY, R ;
SHAUL, Y .
MOLECULAR AND CELLULAR BIOLOGY, 1990, 10 (07) :3683-3689
[9]   HEPATITIS-B-X OPEN READING FRAME DELETION MUTANTS ISOLATED FROM ATYPICAL HEPATITIS-B VIRUS-INFECTIONS [J].
FEITELSON, M ;
DUAN, LX ;
HORIIKE, N ;
CLAYTON, M .
JOURNAL OF HEPATOLOGY, 1991, 13 :S58-S60
[10]  
FEITELSON MA, 1992, GASTROENTEROLOGY, V99, P500