PROSTAGLANDIN E(1) INCREASES INDOCYANINE GREEN DISAPPEARANCE RATE IN PATIENTS WITH CHRONIC LIVER-DISEASE

被引：4

作者：

AONO, T ^{[1
]}

SAKAGUCHI, T ^{[1
]}

TSUKADA, K ^{[1
]}

FUJITA, N ^{[1
]}

ISHIDUKA, D ^{[1
]}

HATAKEYAMA, K ^{[1
]}

机构：

[1] NIIGATA UNIV,SCH MED,DEPT PHYSIOL 1,NIIGATA 951,JAPAN

来源：

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | 1995年 / 23卷 / 04期

关键词：

PROSTAGLANDIN E(1); CIRRHOSIS; LIVER FUNCTION; INDOCYANINE GREEN;

D O I：

10.1177/030006059502300411

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The plasma disappearance rate of indocyanine green was examined after prostaglandin E(1) administration in 11 patients with chronic liver disease. The patients were divided into two groups according to the presence (n = 6) or absence (n = 5) of liver cirrhosis. Indocyanine green (O.1 mg/kg) was introduced as an intravenous bolus 5 min after prostaglandin E(1) administration and the disappearance rate of indocyanine green (ICG-K) was determined by a finger-monitoring method. Saline was injected as the control. Prostaglandin E(1) administration increased ICG-K, and this response was dose dependent when the prostaglandin E(1) dose ranged from 0.01 to 0.05 mu g/kg/min. When ICG-K after prostaglandin E(1) relative to the ICG-K after saline (the control) was defined as the ICG-K ratio, the ICG-K ratio in the;liver cirrhosis group was higher than that in the group without cirrhosis. These findings suggest that prostaglandin E(1) increases the ICG-K of patients with chronic liver disease, and that this is strongest in patients with liver cirrhosis.

引用

页码：299 / 307

页数：9

共 28 条

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