STUDIES ON THE 1-METHYL-4-PHENYL-2,3-DIHYDROPYRIDINIUM SPECIES 2,3-MPDP+, THE MONOAMINE-OXIDASE CATALYZED OXIDATION-PRODUCT OF THE NIGROSTRIATAL TOXIN 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE (MPTP)

被引:65
作者
PETERSON, LA
CALDERA, PS
TREVOR, A
CHIBA, K
CASTAGNOLI, N
机构
[1] UNIV CALIF SAN FRANCISCO,DEPT PHARMACEUT CHEM,SAN FRANCISCO,CA 94143
[2] UNIV CALIF SAN FRANCISCO,DEPT PHARMACOL,SAN FRANCISCO,CA 94143
关键词
D O I
10.1021/jm00148a010
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
收藏
页码:1432 / 1436
页数:5
相关论文
共 23 条
[1]  
ANDERSON PS, 1964, TETRAHEDRON LETT, P153
[2]   IMPROVED DELIVERY THROUGH BIOLOGICAL-MEMBRANES .1. SYNTHESIS AND PROPERTIES OF 1-METHYL-1,6-DIHYDROPYRIDINE-2-CARBALDOXIME, A PRO-DRUG OF N-METHYLPYRIDINIUM-2-CARBALDOXIME CHLORIDE [J].
BODOR, N ;
SHEK, E ;
HIGUCHI, T .
JOURNAL OF MEDICINAL CHEMISTRY, 1976, 19 (01) :102-107
[3]   2-CYANO-DELTA-3-PIPERIDEINES .12. STEREOCHEMISTRY OF FORMATION OF N-BENZYL-2-CYANO-DELTA-3-PIPERIDEINES AND FACILE ISOMERIZATION ON ALUMINA TO 2-CYANO-DELTA-4-PIPERIDEINES - A POTENTIALLY GENERAL-ROUTE TO THE SYNTHESIS OF 2,6-DISUBSTITUTED PIPERIDINE ALKALOIDS [J].
BONIN, M ;
ROMERO, JR ;
GRIERSON, DS ;
HUSSON, HP .
JOURNAL OF ORGANIC CHEMISTRY, 1984, 49 (13) :2392-2400
[4]   A PRIMATE MODEL OF PARKINSONISM - SELECTIVE DESTRUCTION OF DOPAMINERGIC-NEURONS IN THE PARS COMPACTA OF THE SUBSTANTIA NIGRA BY N-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE [J].
BURNS, RS ;
CHIUEH, CC ;
MARKEY, SP ;
EBERT, MH ;
JACOBOWITZ, DM ;
KOPIN, IJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (14) :4546-4550
[5]   METABOLISM OF THE NEUROTOXIC TERTIARY AMINE, MPTP, BY BRAIN MONOAMINE-OXIDASE [J].
CHIBA, K ;
TREVOR, A ;
CASTAGNOLI, N .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1984, 120 (02) :574-578
[6]  
CHIBA K, DRUG METAB DISPOS
[7]   CHRONIC PARKINSONISM SECONDARY TO INTRAVENOUS-INJECTION OF MEPERIDINE ANALOGS [J].
DAVIS, GC ;
WILLIAMS, AC ;
MARKEY, SP ;
EBERT, MH ;
CAINE, ED ;
REICHERT, CM ;
KOPIN, IJ .
PSYCHIATRY RESEARCH, 1979, 1 (03) :249-254
[8]   SYNTHETIC APPLICATIONS OF "2-CYANO-1,2,3,6-TETRAHYDROPYRIDINES - IMPROVED SYNTHESIS OF THE FUNDAMENTAL TETRACYCLIC FRAMEWORK OF DASYCARPIDONE [J].
FELIZ, M ;
BOSCH, J ;
MAULEON, D ;
AMAT, M ;
DOMINGO, A .
JOURNAL OF ORGANIC CHEMISTRY, 1982, 47 (12) :2435-2440
[9]   NEUROTOXICITY OF THE MEPERIDINE ANALOG N-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE ON BRAIN CATECHOLAMINE NEURONS IN THE MOUSE [J].
HALLMAN, H ;
OLSON, L ;
JONSSON, G .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1984, 97 (1-2) :133-136
[10]  
HEIKKILA RE, 1984, FED PROC, V43, P743