INTRAVENOUS ADENOSINE IN THE TREATMENT OF SUPRAVENTRICULAR TACHYCARDIA - A DOSE-RANGING STUDY AND INTERACTION WITH DIPYRIDAMOLE

Increasing doses of adenosine were given by rapid intravenous bolus to seven patients with spontaneous supraventricular tachycardia. Adenosine restored sinus rhythm in 10 of 14 episodes of narrow complex tachycardia. In those patients in whom adenosine produced only transient ventricular slowing the underlying rhythm was atrial flutter. Transient dyspnoea occurred in all patients. In two patients taking dipyridamole the mean dose of adenosine which produced an electrophysiologic effect (restoration of sinus rhythm or ventricular slowing to under 100 beats min-1) was 1.0 .+-. 0.52 mg, whereas in other patients the mean dose was 8.8 .+-. 2.6 mg, suggesting potentiation of the action of adenosine by dipyridamole.