VASOACTIVE-INTESTINAL-PEPTIDE LEVELS IN THE HYPOTHALAMUS AND ANTERIOR-PITUITARY DO NOT CHANGE IN ASSOCIATION WITH THE PREOVULATORY PROLACTIN SURGE IN THE RAT

被引：4

作者：

WATANOBE, H

SASAKI, S

TAKEBE, K

机构：

[1] Third Department of Internal Medicine, Hirosaki University School of Medicine, Hirosaki, Aomori, 036

来源：

NEUROPEPTIDES | 1991年 / 20卷 / 03期

关键词：

D O I：

10.1016/0143-4179(91)90125-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We examined whether vasoactive intestinal peptide (VIP) is involved in the preovulatory prolactin (PRL) surge in the rat. Ovariectomized adult rats implanted sc with an estradiol capsule 2 days previously were decapitated at hourly intervals between 1100-1800 h. The plasma PRL and luteinizing hormone showed an evident surge at 1700 h and 1800 h, respectively. The anterior pituitary PRL content was significantly lower at and after 1600 h than at 1100 h. However, there was no significant change in the VIP content in the suprachiasmatic nucleus, paraventricular nucleus, median eminence or anterior pituitary throughout the entire period of observation. Since all of these regions are known to be involved in the VIP synthesis and/or release, the present results appear to cast some doubt on previous studies reporting a significant role for VIP in the generation of the pre-ovulatory PRL surge.

引用

收藏

页码：159 / 162

页数：4

相关论文

共 24 条

[1] VASOACTIVE INTESTINAL PEPTIDE IS A PHYSIOLOGICAL MEDIATOR OF PROLACTIN-RELEASE IN THE RAT [J].

ABE, H ;

ENGLER, D ;

MOLITCH, ME ;

BOLLINGERGRUBER, J ;

REICHLIN, S .

ENDOCRINOLOGY, 1985, 116 (04) :1383-1390

[2] HYPOTHALAMIC FACTORS INVOLVED IN THE ENDOGENOUS STIMULATORY RHYTHM REGULATING PROLACTIN SECRETION [J].

AREY, BJ ;

FREEMAN, ME .

ENDOCRINOLOGY, 1989, 124 (02) :878-883

[3] VASOACTIVE INTESTINAL POLYPEPTIDE IS SYNTHESIZED IN ANTERIOR-PITUITARY TISSUE [J].

ARNAOUT, MA ;

GARTHWAITE, TL ;

MARTINSON, DR ;

HAGEN, TC .

ENDOCRINOLOGY, 1986, 119 (05) :2052-2057

[4]

BRAR AK, 1985, J ENDOCRINOL, V106, P272

[5] LACTATION ELEVATES VASOACTIVE INTESTINAL PEPTIDE MESSENGER RIBONUCLEIC-ACID IN RAT SUPRACHIASMATIC NUCLEUS [J].

GOZES, I ;

AVIDOR, R ;

BIEGON, A ;

BALDINO, F .

ENDOCRINOLOGY, 1989, 124 (01) :181-186

[6] ANTISERA TO VASOACTIVE INTESTINAL POLYPEPTIDE INHIBIT BASAL PROLACTIN-RELEASE FROM DISPERSED ANTERIOR-PITUITARY-CELLS [J].

HAGEN, TC ;

ARNAOUT, MA ;

SCHERZER, WJ ;

MARTINSON, DR ;

GARTHWAITE, TL .

NEUROENDOCRINOLOGY, 1986, 43 (06) :641-645

[7] ANALYSIS OF PEPTIDE HISTIDINE-ISOLEUCINE VASOACTIVE INTESTINAL POLYPEPTIDE-IMMUNOREACTIVE NEURONS IN THE CENTRAL NERVOUS-SYSTEM WITH SPECIAL REFERENCE TO THEIR RELATION TO CORTICOTROPIN RELEASING FACTOR-LIKE AND ENKEPHALIN-LIKE IMMUNOREACTIVITIES IN THE PARAVENTRICULAR HYPOTHALAMIC NUCLEUSS [J].

HOKFELT, T ;

FAHRENKRUG, J ;

JU, G ;

CECCATELLI, S ;

TSURUO, Y ;

MEISTER, B ;

MUTT, V ;

RUNDGREN, M ;

BRODIN, E ;

TERENIUS, L ;

HULTING, AL ;

WERNER, S ;

BJORKLUND, H ;

VALE, W .

NEUROSCIENCE, 1987, 23 (03) :827-857

[8] ROLE OF OXYTOCIN ON PROLACTIN SECRETION DURING PROESTRUS AND IN DIFFERENT PHYSIOLOGICAL OR PHARMACOLOGICAL PARADIGMS [J].

JOHNSTON, CA ;

NEGROVILAR, A .

ENDOCRINOLOGY, 1988, 122 (01) :341-350

[9] ADMINISTRATION OF ANTISERA TO VASOACTIVE INTESTINAL POLYPEPTIDE AND PEPTIDE HISTIDINE ISOLEUCINE ATTENUATES ETHER-INDUCED PROLACTIN SECRETION IN RATS [J].

KAJI, H ;

CHIHARA, K ;

KITA, T ;

KASHIO, Y ;

OKIMURA, Y ;

FUJITA, T .

NEUROENDOCRINOLOGY, 1985, 41 (06) :529-531

[10]

KALRA SP, 1979, ACTA ENDOCRINOL-COP, V92, P1