ALTERATIONS IN SERUM CORTISOL, CD4+/CD8+ LYMPHOCYTE SUBPOPULATION RATIO AND T-CELL MEDIATED SUPPRESSION OF IMMUNE-RESPONSES IN THE MALNUTRITION OF ANOREXIA-NERVOSA

被引：4

作者：

BENTDAL, OH

FROLAND, SS

DJOSELAND, O

机构：

[1] Institute for Surgical Research, The National Hospital, University of Oslo

[2] Medical Department A, Section of Clinical Immunology and Infectious Diseases, The National Hospital

[3] Medical Department B, Endocrinological Laboratory, Rikshospitalet, The National Hospital, University of Oslo

来源：

CLINICAL NUTRITION | 1991年 / 10卷 / 03期

关键词：

D O I：

10.1016/0261-5614(91)90053-F

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Serum cortisol and T lymphocyte sub-populations (CD3+, 4+ and 8+) were studied in 22 consecutively admitted patients with anorexia nervosa (AN) who had a mean weight loss of 30%. In addition Concanavalin A (Con A) mitogen induced T cell suppression of lymphocyte response to PPD (purified protein derivative of tuberculin antigen) was analysed. Increased serum cortisol concentrations were found in the AN-patients compared to the control group, with mean levels 654 and 418 nmol/l respectively. The relative numbers of CD4+ lymphocytes (mean 36.2%) and the CD4+/CD8+ ratio (mean 1.54) were significantly reduced (p < 0.05) in the AN-patients compared to the control group (mean 41.6% and 2.14 respectively). T cell mediated, Con A induced suppression of lymphocyte response to PPD was increased in AN-patients compared to the control group with low (1-mu-g/ml) Con A concentration, but unchanged with high (5-mu-g/ml) Con A concentration. There was no correlation between serum cortisol concentrations and the numbers of T lymphocyte subpopulations or T cell suppressor activity. In contrast, a highly significant correlation existed between serum cortisol and the duration of AN (p < 0.002), but not with relative weight loss or anthropometric variables: triceps skin-fold (TSF) and arm muscle circumference (AMC). Immunological variables were not correlated with duration of disease. Thus, immunological alterations of the T cell system are detectable in AN, but are subtle and their clinical importance is not well known.

引用

页码：167 / 172

页数：6

共 38 条

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