THERMAL-DEGRADATION OF CLOZAPINE-N-OXIDE TO CLOZAPINE DURING GAS-CHROMATOGRAPHIC ANALYSIS

被引：22

作者：

MARKOWITZ, JS

PATRICK, KS

机构：

[1] MED UNIV S CAROLINA,DEPT PHARMACEUT SCI,CHARLESTON,SC 29425

[2] MED UNIV S CAROLINA,DEPT HOSP PHARM PRACTICE & ADM,CHARLESTON,SC 29425

来源：

JOURNAL OF CHROMATOGRAPHY B-BIOMEDICAL APPLICATIONS | 1995年 / 668卷 / 01期

关键词：

D O I：

10.1016/0378-4347(95)00060-V

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Studies were undertaken to determine if clozapine-N-oxide, the principal urinary metabolite of the antipsychotic agent clozapine, may interfere with the gas chromatographic-mass spectrometric bioanalysis of clozapine. Following injection of clozapine-N-oxide onto a (5% phenyl)methylpolysiloxane capillary column operated at 250 degrees C, significant on-column reduction of clozapine-N-oxide to the parent drug occurred. Accordingly, preparation of biological samples for clozapine determination by gas chromatography should avoid conditions which reportedly co-extract the N-oxide to assure no artifactual contribution of this metabolite in the detection of clozapine.

引用

页码：171 / 174

页数：4

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