PROCOLLAGEN TYPE-I C-TERMINAL EXTENSION PEPTIDE IN PREDIALYSIS CHRONIC-RENAL-FAILURE

被引:31
作者
COEN, G [1 ]
MAZZAFERRO, S [1 ]
BALLANTI, P [1 ]
BONUCCI, E [1 ]
BONDATTI, F [1 ]
MANNI, M [1 ]
PASQUALI, M [1 ]
PERRUZZA, I [1 ]
SARDELLA, D [1 ]
SPURIO, A [1 ]
机构
[1] LA SAPIENZA UNIV,DEPT HUMAN BIOPATHOL,I-00161 ROME,ITALY
关键词
PROCOLLAGEN TYPE-1; BONE FORMATION PARAMETERS; OSTEOCALCIN; PARATHYROID HORMONE; 1,25-DIHYDROXYVITAMIN-D(3); NONDIALYTIC CHRONIC RENAL FAILURE;
D O I
10.1159/000168453
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Collagen type 1 is the most abundant protein of bone. Serum levels of type 1 procollagen carboxy-terminal extension peptide (Procoll-1-C) may give a measure of the rate of synthesis of the collagen of bone and be therefore a marker of bone turnover. We have studied 38 patients with predialysis chronic renal failure; 14 of them were under long-term treatment with 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] for prevention of secondary hyperparathyroidism. In all patients a transiliac bone biopsy for histomorphometry and determination of dynamic parameters was performed following double tetracycline labeling. In addition serum Procoll-1-C, intact and C-terminal parathyroid hormone (PTH), osteocalcin and alkaline phosphatase were determined. In the patients not receiving 1,25(OH)2D3, serum levels of Procoll-1-C were higher than normal. Procoll-1-C did not correlate with any of the humoral parameters, including serum creatinine, nor with static histomorphometric parameters. Contrarily to osteocalcin, the collagen type 1 marker correlated significantly with all dynamic parameters. Treatment with 1,25(OH)2D3 was accompanied by lower levels of osteocalcin, iPTH (n.s.), osteoblastic surface and by normal levels of Procoll-l-C (p < 0.001, compared to untreated patients), without substantial change in bone formation parameters (bone formation rate). In conclusion Procoll-1-C in predialysis chronic renal failure is a marker of bone turnover unparalleled by other markers. 1,25(OH)2D3 administration is associated with lower serum levels of the peptide unaccompanied by a decrement of bone formation parameters, therefore with an apparently better utilization of collagen type 1 in the mineralization process. The role of PTH in the procollagen type 1 synthesis in predialysis chronic renal failure remains undetermined.
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页码:246 / 251
页数:6
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