EXPRESSION OF HOX-4 GENES IN THE CHICK WING LINKS PATTERN-FORMATION TO THE EPITHELIAL MESENCHYMAL INTERACTIONS THAT MEDIATE GROWTH

被引：45

作者：

IZPISUABELMONTE, JC

BROWN, JM

DUBOULE, D

TICKLE, C

机构：

[1] EUROPEAN MOLEC BIOL LAB,W-6900 HEIDELBERG,GERMANY

[2] UNIV COLL & MIDDLESEX SCH MED,DEPT ANAT & DEV BIOL,LONDON W1P 6DB,ENGLAND

来源：

EMBO JOURNAL | 1992年 / 11卷 / 04期

关键词：

APICAL RIDGE; EPITHELIAL MESENCHYMAL INTERACTION; HOX-4; GENES; LIMB DEVELOPMENT; RETINOIC ACID;

D O I：

10.1002/j.1460-2075.1992.tb05189.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The relationship between the expression of Hox-4 genes in the mesenchyme and the apical ectodermal ridge was investigated in both normal chick wing buds and wing buds treated with retinoic acid. Two conclusions emerge. One is that the activation of Hox-4 domains and the elaboration of Hox-4 gene expression patterns involve cooperation with a signal from the apical ridge. The second is that the domains of expression of 5'-located members of the complex correlate with the maintenance of the thickened ridge which is required for subsequent bud outgrowth.

引用

页码：1451 / 1457

页数：7

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