[RUO(DPPZ)(TPY)]2+ - A DNA CLEAVAGE AGENT WITH HIGH DNA AFFINITY

被引：99

作者：

GUPTA, N ^{[1
]}

GROVER, N ^{[1
]}

NEYHART, GA ^{[1
]}

LIANG, WG ^{[1
]}

SINGH, P ^{[1
]}

THORP, HH ^{[1
]}

机构：

[1] N CAROLINA STATE UNIV,DEPT CHEM,RALEIGH,NC 27695

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1992年 / 31卷 / 08期

关键词：

D O I：

10.1002/anie.199210481

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A Ru(IV)O functional unit and an intercalating heteroligand, dipyridophenazine (dppz), are united in the complex cation of the title, 1, and responsible for its high DNA-cleavage activity and DNA affinity. In the solid state, the units of the RuOH2 analogue of 1 (ClO4-counterion) are linked by pi-stacking interactions similar to those in acridine orange and other conventional intercalators; the distance between the dppz ligands is 3.5 angstrom tpy = 2,2',2",-terpyridine.

引用

页码：1048 / 1050

页数：3

共 22 条

[1] METALS AND DNA - MOLECULAR LEFT-HANDED COMPLEMENTS
BARTON, JK
[J]. SCIENCE, 1986, 233 (4765) : 727 - 734
[2] SYNTHESIS, CHARACTERIZATION, AND DNA-BINDING PROPERTIES OF (1,2-DIAMINOETHANE)PLATINUM(II) COMPLEXES LINKED TO THE DNA INTERCALATOR ACRIDINE-ORANGE BY TRIMETHYLENE AND HEXAMETHYLENE CHAINS
BOWLER, BE
AHMED, KJ
SUNDQUIST, WI
HOLLIS, LS
WHANG, EE
LIPPARD, SJ
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1989, 111 (04) : 1299 - 1306
[3] THE UNUSUAL CONFORMATION ADOPTED BY THE ADENINE TRACTS IN KINETOPLAST DNA
BURKHOFF, AM
TULLIUS, TD
[J]. CELL, 1987, 48 (06) : 935 - 943
[4] STRUCTURAL DETAILS OF AN ADENINE TRACT THAT DOES NOT CAUSE DNA TO BEND
BURKHOFF, AM
TULLIUS, TD
[J]. NATURE, 1988, 331 (6155) : 455 - 457
[5] VOLTAMMETRIC STUDIES OF THE INTERACTION OF METAL-CHELATES WITH DNA .2. TRIS-CHELATED COMPLEXES OF COBALT(III) AND IRON(II) WITH 1,10-PHENANTHROLINE AND 2,2'-BIPYRIDINE
CARTER, MT
RODRIGUEZ, M
BARD, AJ
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1989, 111 (24) : 8901 - 8911
[6] DESIGN, SYNTHESIS, AND DNA-BINDING PROPERTIES OF BIFUNCTIONAL INTERCALATORS - COMPARISON OF POLYMETHYLENE AND DIPHENYL ETHER CHAINS CONNECTING PHENANTHRIDINE
CORY, M
MCKEE, DD
KAGAN, J
HENRY, DW
MILLER, JA
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1985, 107 (08) : 2528 - 2536
[7] DESIGN OF SEQUENCE-SPECIFIC DNA-BINDING MOLECULES
DERVAN, PB
[J]. SCIENCE, 1986, 232 (4749) : 464 - 471
[8] MOLECULAR LIGHT SWITCH FOR DNA - RU(BPY)2(DPPZ)2+
FRIEDMAN, AE
CHAMBRON, JC
SAUVAGE, JP
TURRO, NJ
BARTON, JK
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1990, 112 (12) : 4960 - 4962
[9] STUDIES OF ELECTROCATALYTIC DNA CLEAVAGE BY OXORUTHENIUM(IV) - X-RAY CRYSTAL-STRUCTURE OF [RU(TPY)(TMEN)OH2](CLO4)2 (TMEN = N,N,N',N'-TETRAMETHYLETHYLENEDIAMINE, TPY = 2,2',2''-TERPYRIDINE)
GROVER, N
GUPTA, N
SINGH, P
THORP, HH
[J]. INORGANIC CHEMISTRY, 1992, 31 (11) : 2014 - 2020
[10] EFFICIENT ELECTROCATALYTIC AND STOICHIOMETRIC OXIDATIVE CLEAVAGE OF DNA BY OXORUTHENIUM(IV)
GROVER, N
THORP, HH
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1991, 113 (18) : 7030 - 7031

← 1 2 3 →