CELL-SHAPE AND ARRANGEMENT OF CULTURED AORTIC SMOOTH-MUSCLE CELLS GROWN ON COLLAGEN GELS

被引：13

作者：

AKITA, M ^{[1
]}

MURATA, E ^{[1
]}

KANEKO, K ^{[1
]}

GHAIDA, J ^{[1
]}

MERKER, HJ ^{[1
]}

机构：

[1] FREE UNIV BERLIN,INST TOXICOL & PRENATAL PHARMACOL,D-14195 BERLIN,GERMANY

来源：

CELL AND TISSUE RESEARCH | 1993年 / 274卷 / 01期

关键词：

SMOOTH MUSCLE CELLS; CELL SHAPE; CELL ARRANGEMENT; COLLAGEN GEL; CELL CULTURE; AORTA; RAT (WISTAR);

D O I：

10.1007/BF00327989

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Aortic smooth muscle cells (SMC) grown on conventional plastic culture dishes have morphological and functional properties of dedifferentiated cells in subculture. We examined the influence of collagen gels on the cell shape and arrangement. The cells grown on collagen gels showed a multilayered growth with formation of nodules. When the edge of the collagen gels was detached from the culture dish, the shape and arrangement of cells on the edge differed from that of the central, still attached region. The cells grown on floating collagen gels exhibited a spindle-like shape and were arranged in concentric circles. These findings suggest that the physical property of the substrate influences the cell shape and arrangement.

引用

页码：91 / 95

页数：5

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