SYNTHETIC STUDIES ON ANTIBIOTIC DYNEMICIN-A - SYNTHESIS OF CYCLIC ENEDIYNE MODEL-COMPOUND OF DYNEMICIN-A

被引：55

作者：

NISHIKAWA, T ^{[1
]}

INO, A ^{[1
]}

ISOBE, M ^{[1
]}

机构：

[1] NAGOYA UNIV,SCH AGR,ORGAN CHEM LAB,CHIKUSA KU,NAGOYA 46401,JAPAN

来源：

TETRAHEDRON | 1994年 / 50卷 / 05期

关键词：

D O I：

10.1016/S0040-4020(01)80629-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Dynemicin A, a potent antitumor antibiotic has novel 10-membered cyclic enediyne moiety. The bicyclo[7.3.1]-tridecadiyne system having aniline moiety of this antibiotic was designed and synthesized from lepidine in 10 steps. The synthesized compound can be cycloaromatized to Bergman product via pinacol rearrangement under acidic condition, and also exhibited DNA cleaving activity.

引用

页码：1449 / 1468

页数：20

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