REGULATION AND EXPRESSION OF THE HUMAN APOLIPOPROTEIN-E GENE IN TRANSGENIC MICE

被引：12

作者：

TAYLOR, JM ^{[1
]}

SIMONET, WS ^{[1
]}

LAUER, SJ ^{[1
]}

ZHU, GM ^{[1
]}

WALKER, D ^{[1
]}

机构：

[1] UNIV CALIF SAN FRANCISCO,GLADSTONE INST CARDIOVASC DIS,DEPT PHYSIOL,CARDIOVASC RES INST,SAN FRANCISCO,CA 94141

来源：

CURRENT OPINION IN LIPIDOLOGY | 1993年 / 4卷 / 02期

关键词：

D O I：

10.1097/00041433-199304000-00002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The expression of the apolipoprotein (apo) E and C-I genes in different tissues is determined by distinct regulatory elements that are distributed upstream and downstream of these genes, including a common hepatic control region that is located 18 kb downstream of the apoE gene promoter. The hepatic control region contains all of the sequences needed to direct expression to the liver, but it requires the presence of a non-specific regulatory element in the proximal promoter of the apoE gene for its action.

引用

页码：84 / 89

页数：6

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