SYNTHESIS OF (-)-BULLATACIN - THE ENANTIOMER OF A POTENT, ANTITUMOR, 4-HYDROXYLATED, ANNONACEOUS ACETOGENIN

被引：77

作者：

HOYE, TR

HANSON, PR

机构：

[1] Department of Chemistry University of Minnesota, Minneapolis

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 32期

关键词：

D O I：

10.1016/S0040-4039(00)60671-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthesis of the title compound represents the first construction of any of these potent, antitumor Annonaceous acetogenins with the entire relative stereochemistry in place. Palladium(0)-mediated crossed diyne coupling and the use of three, natural, alpha-hydroxy acids as the origin of all absolute stereochemistry highlight this flexible approach that sets the stage for access to structural analogs for further study.

引用

页码：5043 / 5046

页数：4

共 24 条

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