NOVEL CHOLECYSTOKININ RECEPTOR LIGANDS OXOPIPERAZINES DERIVED FROM BOC-CCK-4

被引：14

作者：

BATT, AR ^{[1
]}

KENDRICK, DA ^{[1
]}

MATHEWS, E ^{[1
]}

ROOKER, DP ^{[1
]}

RYDER, H ^{[1
]}

SEMPLE, G ^{[1
]}

SZELKE, M ^{[1
]}

机构：

[1] UNIV SOUTHAMPTON,RES CTR,FERRING RES INST,SOUTHAMPTON SO1 7NP,ENGLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 07期

关键词：

D O I：

10.1016/S0960-894X(01)80253-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Replacement of the C-terminal dipeptide amide of Boc-CCK-4 (1) with oxopiperazines yields a series of weak CCK-receptor ligands. Further modifications result in more potent and receptor subtype selective compounds.

引用

页码：867 / 872

页数：6

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