COMPARISON OF T2 RELAXATION IN BLOOD, BRAIN, AND FERRITIN

被引：65

作者：

BROOKS, RA

VYMAZAL, J

BULTE, JWM

BAUMGARNER, CD

TRAN, V

机构：

[1] National institute of Neurological, National institutes or Health, Bethesda, Maryland

[2] Laboratory of Diagnostic Radiology Research, National institutes or Health, Bethesda, Maryland

来源：

JMRI-JOURNAL OF MAGNETIC RESONANCE IMAGING | 1995年 / 5卷 / 04期

关键词：

BRAIN IRON; FERRITIN; BLOOD; HEMOGLOBIN; T2-SHORTENING; DIFFUSION;

D O I：

10.1002/jmri.1880050414

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

T2 was measured in samples of human blood and monkey brain over a held range of 0.02-1.5 Tesla, with variable interecho times, and was compared with previous data on ferritin solutions [taken with the same apparatu]. 1/T2 in deoxygenated blood increased quadratically with field strength, as noted previously, but in brain gray matter the increase was linear, as also was the case in ferritin solution. In both deoxygenated blood and gray matter, 1/T2 increased with interecho time, but appeared to level off at times around 50 msec, as expected from the theory of diffusion through magnetic gradients. Diffusion times estimated by using the chemical exchange approximation were 3.4 msec for deoxygenated blood and 5.7 msec for the globus pallidus. The quadratic held dependence in blood is consistent with this same theory, but the linear dependence in brain tissue and in ferritin solutions remains unexplained.

引用

页码：446 / 450

页数：5

共 33 条

[1] Thulborn KR, Waterton JC, Matthews PM, Radda GK, Oxygenated dependence of the transverse relaxation time of water protons in the whole blood at high field, Biochim Biophys Acta, 714, pp. 265-270, (1982)
[2] Ogawa S, Lee T-M, Nayak AS, Glynn P, Oxygenation‐sensitive contrast in magnetic resonance image of rodent brain at high magnetic fields, Magn Reson Med, 14, pp. 68-78, (1990)
[3] Brooks RA, Di Chiro G, Magnetic resonance imaging of stationary blood: a review, Med Phys, 14, pp. 903-913, (1987)
[4] Gomori JM, Grossman, Yu-lp C, Asakura T, NMR relaxation times of blood: dependence on field strength, oxidation state, and cell integrity, J Comput Assist Tomogr, 11, pp. 684-690, (1987)
[5] Drayer B, Burger P, Darwin R, Riederer S, Herfkens R, Johnson GA, Magnetic resonance imaging of brain iron, AJNR, 7, pp. 373-380, (1986)
[6] Bizzi A, Brooks RA, Brunetti A, Hill JM, Alger JR, Miletich RS, Francavilla TL, Di Chiro G, Role of iron and ferritin in MR imaging of the brain: a study in primates at different field strengths, Radiology, 177, pp. 59-65, (1990)
[7] Vymazal J, Brooks RA, Zak O, McRill C, Shen C, Dl Chiro G, T1 and T2 of ferritin at different field strengths: effect on MRI, Magn Reson Med, 27, pp. 368-374, (1992)
[8] Kucharczyk W, Henkelman RM, Chen J, (Letter) Brain iron and T2 signal, Am J Neuroradiol, 15, pp. 1795-1796, (1994)
[9] Bauminger ER, Cohen SG, Ofer S, Rachmilewitz EA, Quantitative studies of ferritin‐like iron in erythrocytes of thal‐assemia, sickle cell anemia and hemoglobin Hammersmith with Mossbauer spectroscopy, Proc Nat Acad Sci USA, 76, pp. 939-943, (1979)
[10] Koenig SH, Brown RD, Determinants of proton relaxation rates in tissue, Magn Reson Med, 1, pp. 437-449, (1984)

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