FORMATION OF NITROGEN-OXIDES INCLUDING NO FROM OXIDATIVE CLEAVAGE OF C=N(OH) BONDS - A GENERAL CYTOCHROME P450-DEPENDENT REACTION

被引：37

作者：

JOUSSERANDOT, A

BOUCHER, JL

DESSEAUX, C

DELAFORGE, M

MANSUY, D

机构：

[1] Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques (URA 400), Université Paris V, 75270 Paris Cedex 06

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 05期

关键词：

D O I：

10.1016/0960-894X(95)00048-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Several compounds such as aldoximes, ketoximes, amidoximes and guanidoximes were oxidized by liver microsomes from dexamethasone-treated rats with formation of nitrogen oxides such as NO2-, NO3- and NO. The oxidative cleavage of their C=N(OH) bond appears as a general P450 3A-catalyzed reaction, which is particularly efficient in the case of N,N'-disubstituted guanidoximes.

引用

页码：423 / 426

页数：4

共 18 条

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