EFFECTS OF NIFEDIPINE ON LEFT-VENTRICULAR DIASTOLIC FUNCTION IN HYPERTENSION - ECHO DOPPLER STUDY

被引：15

作者：

GAMBELLI, G

AMICI, E

SELVANETTI, A

机构：

[1] Clinica Valle Giulia, Rome, 00197

来源：

CARDIOVASCULAR DRUGS AND THERAPY | 1990年 / 4卷

关键词：

DOPPLER ECHOCARDIOGRAPHY; ISOVOLUMIC RELAXATION TIME; DIASTOLIC LEFT VENTRICULAR FILLING; NIFEDIPINE; CALCIUM ANTAGONISTS;

D O I：

10.1007/BF02018299

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Hypertensive cardiac disease shows early alteration of left ventricular diastolic filling, characterized by a longer isovolumetric relaxation period and by an altered E/A ratio on the mitral spectral Doppler. We chose ten hypertensive patients who had left ventricular hypertrophy, but no left ventricular dilatation or mitral valve insufficiency and had a good left ventricular shortening fraction (> 26%). After the washout period we studied each of the above-mentioned parameters before and after the acute administration of nifedipine, dinitrate isosorbide, and captopril. While captopril and dinitrate isosorbide induced a prolongation of the isovolumic relaxation time and an impairment of the E/A ratio in mitral spectral Doppler (i.e., left ventricular filling), nifedipine induced an improvement in both parameters. The three drugs also induced a similar reduction in systemic blood pressure values (i.e., similar afterload). We therefore suggest that changes in diastolic function in hypertrophied cardiac fibers, induced by nifedipine, may be the result of a double action: one mediated by hemodynamic changes, the other directly affecting the cellular calcium ion exchange.

引用

页码：951 / 956

页数：6

共 33 条

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