ENZYME-MEDIATED ENANTIOSELECTIVE ACYLATION OF SECONDARY-AMINES IN ORGANIC-SOLVENTS

被引：33

作者：

ASENSIO, G

ANDREU, C

MARCO, JA

机构：

[1] Universidad de Valencia, Departamento de Q. Orgánica, Facultad de Farmacia

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 33期

关键词：

D O I：

10.1016/S0040-4039(00)79903-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Porcine pancreatic lipase (PPL) and lipase Amano P catalyze the enantioselective acylation of cyclic 1,2- and 1,3-amino alcohol derivatives in organic solvents. The enantiomeric excesses (ee's) were shown to depend on the enzyme, reaction time, temperature and type of substrate.

引用

页码：4197 / 4198

页数：2

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