TOLERANCE AND SENSITIZATION TO CHRONIC AND SUBCHRONIC ORAL CAFFEINE - EFFECTS ON WHEELRUNNING IN RATS

被引：23

作者：

MELISKA, CJ

LANDRUM, RE

LANDRUM, TA

机构：

[1] Department of Psychology, Southern Illinois University at Carbondale, Carbondale

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1990年 / 35卷 / 02期

关键词：

Caffeine; Chronic administration; Subchronic administration; Wheelrunning;

D O I：

10.1016/0091-3057(90)90189-O

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Twenty-four male Sprague-Dawley rats were tested for wheelrunning in conjunction with chronic (continuous) or subchronic (alternate day) oral caffeine administration. As expected, chronic administration led to complete tolerance to caffeine's locomotor stimulant effect, while subchronic administration produced sensitization. Results confirm earlier reports of enhanced stimulation with spaced administration of caffeine and tolerance with chronic administration. © 1990.

引用

页码：477 / 479

页数：3

共 12 条

[1] EFFECTS OF CAFFEINE, THEOPHYLLINE AND THEOBROMINE ON SCHEDULED CONTROLLED RESPONDING IN RATS [J].