SPECTRAL-ANALYSIS OF THE EEG AND 99M-TC-HMPAO SPECT-SCAN IN ALZHEIMERS-DISEASE

被引：42

作者：

KWA, VIH

WEINSTEIN, HC

MEYJES, EFP

VANROYEN, EA

BOUR, LJ

VERHOEFF, PNLG

DEVISSER, BWO

机构：

[1] UNIV AMSTERDAM,ACAD MED CTR,DEPT CLIN NEUROPHYSIOL,1105 AZ AMSTERDAM,NETHERLANDS

[2] UNIV AMSTERDAM,ACAD MED CTR,DEPT NUCL MED,1105 AZ AMSTERDAM,NETHERLANDS

[3] FREE UNIV AMSTERDAM,PCA VALERIVSKLIN,1007 MC AMSTERDAM,NETHERLANDS

来源：

BIOLOGICAL PSYCHIATRY | 1993年 / 33卷 / 02期

关键词：

D O I：

10.1016/0006-3223(93)90308-Z

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

99m-technetium-hexamethylpropylene-amineoxine (99m-Tc-HMPAO) single-photon-emission-computer-tomography (SPECT)-scans and spectral analyzed electroencephalogram (EEGs) of 20 patients with Alzheimer's disease (AD) were studied. A significant correlation was found between the temporoparietal-cerebellar-ratio (TP/C-ratio) of the SPECT-scan and the peak frequencies of leads T3-T5, C3-P3, and C4-P4 of the EEG. In addition a significant negative correlation between the TP/C-ratio and the theta/alpha-ratio (t/a-ratio) of leads T3-T5, T4-T6, C3-P3, and C4-P4 was demonstrated. Our study demonstrates that slowing of the EEG parallels a decrease in blood flow in the temporoparietal regions in AD-patients. Both findings could be parallel phenomena of regional hypometabolism.

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页码：100 / 107

页数：8

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