SEQUENCE DETERMINATION OF ACTAGARDINE, A NOVEL LANTIBIOTIC, BY HOMONUCLEAR 2D NMR-SPECTROSCOPY

被引:20
作者
KETTENRING, JK
MALABARBA, A
VEKEY, K
CAVALLERI, B
机构
[1] Merrell DowResearch Institute — Lepetit Research Center, Varese, Via R. Lepetit 34
关键词
D O I
10.7164/antibiotics.43.1082
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
By combination of several 1H NMR techniques, the sequence of actagardine has been elucidated. It has been shown that it is a tetracyclic 19-residue peptide antibiotic. It differs from the previously described lanthionine-containing peptide antibiotics belonging to the lantibiotic class. © 1990, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.
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页码:1082 / 1088
页数:7
相关论文
共 15 条
[1]   CONFIRMATION OF THE STRUCTURE OF NISIN AND ITS MAJOR DEGRADATION PRODUCT BY FAB-MS AND FAB-MS/MS [J].
BARBER, M ;
ELLIOT, GJ ;
BORDOLI, RS ;
GREEN, BN ;
BYCROFT, BW .
EXPERIENTIA, 1988, 44 (03) :266-270
[2]   MLEV-17-BASED TWO-DIMENSIONAL HOMONUCLEAR MAGNETIZATION TRANSFER SPECTROSCOPY [J].
BAX, A ;
DAVIS, DG .
JOURNAL OF MAGNETIC RESONANCE, 1985, 65 (02) :355-360
[3]   COMPARATIVE STUDIES OF CONFORMATION AND INTERNAL MOBILITY IN NATIVE AND CIRCULAR BASIC PANCREATIC TRYPSIN-INHIBITOR BY H-1 NUCLEAR MAGNETIC-RESONANCE IN SOLUTION [J].
CHAZIN, WJ ;
GOLDENBERG, DP ;
CREIGHTON, TE ;
WUTHRICH, K .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1985, 152 (02) :429-437
[4]   GARDIMYCIN, A NEW ANTIBIOTIC FROM ACTINOPLANES .2. ISOLATION AND PRELIMINARY CHARACTERIZATION [J].
CORONELLI, C ;
TAMONI, G ;
LANCINI, GC .
JOURNAL OF ANTIBIOTICS, 1976, 29 (05) :507-510
[5]  
GANGULI BN, 1989, 29TH INT C ANT AG CH, V413, P169
[6]   GALLIDERMIN - A NEW LANTHIONINE-CONTAINING POLYPEPTIDE ANTIBIOTIC [J].
KELLNER, R ;
JUNG, G ;
HORNER, T ;
ZAHNER, H ;
SCHNELL, N ;
ENTIAN, KD ;
GOTZ, F .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1988, 177 (01) :53-59
[7]   PEP5 - STRUCTURE ELUCIDATION OF A LARGE LANTIBIOTIC [J].
KELLNER, R ;
JUNG, G ;
JOSTEN, M ;
KALETTA, C ;
ENTIAN, KD ;
SAHL, HG .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 1989, 28 (05) :616-619
[8]   COMPLETE SEQUENCE DETERMINATION AND LOCALIZATION OF ONE IMINO AND 3 SULFIDE BRIDGES OF THE NONADECAPEPTIDE RO-09-0198 BY HOMONUCLEAR 2D-NMR SPECTROSCOPY - THE DQF-RELAYED-NOESY-EXPERIMENT [J].
KESSLER, H ;
STEUERNAGEL, S ;
GILLESSEN, D ;
KAMIYAMA, T .
HELVETICA CHIMICA ACTA, 1987, 70 (03) :726-741
[9]   THE RELEVANCE OF J-CROSS-PEAKS IN TWO-DIMENSIONAL NOE EXPERIMENTS OF MACROMOLECULES [J].
MACURA, S ;
WUTHRICH, K ;
ERNST, RR .
JOURNAL OF MAGNETIC RESONANCE, 1982, 47 (02) :351-357
[10]   SYNTHESIS AND BIOLOGICAL-ACTIVITY OF SOME AMIDE DERIVATIVES OF THE LANTIBIOTIC ACTAGARDINE [J].
MALABARBA, A ;
PALLANZA, R ;
BERTI, M ;
CAVALLERI, B .
JOURNAL OF ANTIBIOTICS, 1990, 43 (09) :1089-1097