INVOLVEMENT OF PROTEIN-KINASE ACTIVATION IN NEUROTROPHIC EFFECTS OF BASIC FIBROBLAST GROWTH-FACTOR IN CULTURED BRAIN NEURONS

被引：7

作者：

ABE, K

IRI, Y

TAKAYANAGI, M

SAITO, H

机构：

[1] Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo

来源：

JAPANESE JOURNAL OF PHARMACOLOGY | 1991年 / 56卷 / 04期

关键词：

D O I：

10.1254/jjp.56.563

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The influences of K-252a and staurosporine, protein kinase inhibitors, on neurotrophic effects of basic fibroblast growth factor (bFGF) were investigated in dissociated cell cultures of the striatum, hippocampus and cerebellum of fetal rats. Addition of 1 ng/ml bFGF enhanced the survival of cultured neurons of all brain regions tested. Both K-252a (10-200 nM) and staurosporine (1-100 nM) blocked the survival promoting effects of bFGF in a concentration-dependent manner. These results suggest that bFGF exerts its neurotrophic effects through activation of protein kinase(s).

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页码：563 / 566

页数：4

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