METALLOTHIONEIN LEVELS IN OVARIAN-TUMORS BEFORE AND AFTER CHEMOTHERAPY

被引:51
作者
MURPHY, D
MCGOWN, AT
CROWTHER, D
MANDER, A
FOX, BW
机构
[1] CHRISTIE HOSP & HOLT RADIUM INST, PATERSON INST CANC RES, DEPT EXPTL CHEMOTHERAPY, MANCHESTER M20 9BX, LANCS, ENGLAND
[2] CHRISTIE HOSP & HOLT RADIUM INST, PATERSON INST CANC RES, CANC RES CAMPAIGN, DEPT MED ONCOL, MANCHESTER M20 9BX, LANCS, ENGLAND
[3] ROYAL OLDHAM HOSP, OLDHAM, LANCS, ENGLAND
关键词
D O I
10.1038/bjc.1991.160
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The metallothionein content of ovarian tumours is considerably higher than that found in normal ovaries (> 100-fold differences in mean values, P < 0.001). There was no difference between the metallothionein content of tumours from patients who had completed chemotherapy, usually with a regimen containing a platinum drug, and tumours from untreated patients. Similarly, the level of metallothionein was not influenced by response to therapy, age, stage, histology, or tumour cell differentiation state. These data do not support the hypothesis that metallothionein content is a major determinant of tumour sensitivity in ovarian cancer.
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收藏
页码:711 / 714
页数:4
相关论文
共 14 条
[1]  
ANDREWS PA, 1987, CANCER CHEMOTH PHARM, V19, P149
[2]   RESISTANCE AGAINST CIS-DICHLORODIAMMINEPLATINUM IN CULTURED-CELLS WITH A HIGH CONTENT OF METALLOTHIONEIN [J].
BAKKA, A ;
ENDRESEN, L ;
JOHNSEN, ABS ;
EDMINSON, PD ;
RUGSTAD, HE .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 1981, 61 (02) :215-226
[3]  
BEHRENS BC, 1987, CANCER RES, V47, P414
[4]  
ENDRESEN L, 1984, ACTA PHARMACOL TOX, V55, P183
[5]  
GURNEY H, 1990, IN PRESS ANN ONCOL
[6]   OVEREXPRESSED HUMAN METALLOTHIONEIN-IIA GENE PROTECTS CHINESE HAMSTER OVARY CELLS FROM KILLING BY ALKYLATING-AGENTS [J].
KAINA, B ;
LOHRER, H ;
KARIN, M ;
HERRLICH, P .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (07) :2710-2714
[7]   THE HUMAN METALLOTHIONEIN GENE FAMILY - STRUCTURE AND EXPRESSION [J].
KARIN, M ;
RICHARDS, RI .
ENVIRONMENTAL HEALTH PERSPECTIVES, 1984, 54 (MAR) :111-115
[8]   OVEREXPRESSION OF METALLOTHIONEIN CONFERS RESISTANCE TO ANTICANCER DRUGS [J].
KELLEY, SL ;
BASU, A ;
TEICHER, BA ;
HACKER, MP ;
HAMER, DH ;
LAZO, JS .
SCIENCE, 1988, 241 (4874) :1813-1815
[9]  
Nash J D, 1988, Cancer Chemother Biol Response Modif, V10, P291
[10]   HIGH-DOSE CISPLATIN IN HYPERTONIC SALINE IN REFRACTORY OVARIAN-CANCER [J].
OZOLS, RF ;
OSTCHEGA, Y ;
MYERS, CE ;
YOUNG, RC .
JOURNAL OF CLINICAL ONCOLOGY, 1985, 3 (09) :1246-1250