ANALYSIS OF SPERM CHROMOSOME COMPLEMENTS FROM A MAN HETEROZYGOUS FOR A ROBERTSONIAN TRANSLOCATION 45,XY,T(15Q 22Q)

被引：33

作者：

MARTIN, RH ^{[1
]}

HILDEBRAND, K ^{[1
]}

KO, E ^{[1
]}

机构：

[1] UNIV CALGARY,FAC MED,DEPT PEDIAT,DIV MED GENET,CALGARY T2N 1N4,ALBERTA,CANADA

来源：

AMERICAN JOURNAL OF MEDICAL GENETICS | 1992年 / 43卷 / 05期

关键词：

HUMAN SPERM CHROMOSOMES; SEGREGATION OF ROBERTSONIAN TRANSLOCATIONS; MEIOSIS IN ROB T(15 22);

D O I：

10.1002/ajmg.1320430520

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Chromosome complements were studied in 118 sperm from a man heterozygous for a 15;22 Robertsonian translocation using the human sperm/hamster oocyte fusion technique. Alternate segregation occurred in most spreads (89.6%) and the proportion of normal (42.6%) and balanced complements (47%) was approximately equal. The frequency of sperm that were unbalanced with respect to the translocation was 10.4% and all categories of unbalanced sperm were observed (-15,-22,+ 15,+ 22). The frequency of chromosome abnormalities unrelated to the translocation was 7.6%. Since the frequencies of both numerical (3.4%) and structural abnormalities (3.4%) were within the normal range of control donors, there was no evidence for an interchromosomal effect. The frequencies of X-chromosome bearing (48%) and Y-chromsome bearing (52%) sperm were not significantly different from 50%. Data on this translocation were compared to the 4 other reports of cytogenetic analysis in sperm of Robertsonian translocation carriers.

引用

页码：855 / 857

页数：3

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