SYNTHESIS AND PROPERTIES OF [R-(Z)]-(+)-ALPHA-(1-AZABICYCLO[2.2.2]OCT-3-YL)-ALPHA-(METHOXYIMINO) ACETONITRILE, A NOVEL FUNCTIONALLY SELECTIVE MUSCARINIC PARTIAL AGONIST

被引：9

作者：

BROMIDGE, SM ^{[1
]}

CASSIDY, F ^{[1
]}

CLARK, MSG ^{[1
]}

EGGLESTON, DS ^{[1
]}

ORIEK, BS ^{[1
]}

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT, DISCOVERY RES, DEPT MOLEC NEUROPATHOL, HARLOW CM19 5AD, ESSEX, ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1994年 / 18期

关键词：

D O I：

10.1039/c39940002189

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The (Z)-N-methoxy imidoyl nitrile functionality is a novel methyl ester bioisostere, which, when substituted onto the quinuclidine ring system gives the title compound 1, a stable, brain penetrant and functionally selective muscarinic; partial agonist; X-ray studies confirm the configurational assignment and reveal that the imino and cyano bond lengths are consistent with those expected for formal double and triple bonds, respectively.

引用

页码：2189 / 2190

页数：2

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