ENANTIOSELECTIVE SYNTHESIS OF NCA (S)-L-([ALPHA-C-11]METHYL)-TRYPTOPHAN

被引：13

作者：

PLENEVAUX, A

LEMAIRE, C

DELFIORE, G

COMAR, D

机构：

[1] Cyclotron Research Center, Liège University

来源：

APPLIED RADIATION AND ISOTOPES | 1994年 / 45卷 / 06期

关键词：

D O I：

10.1016/0969-8043(94)90242-9

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

N.c.a. (S)-L-([alpha-C-11]methyl)-tryptophan was prepared by treatment at -78-degrees-C of (2S,3aR,8aS)-1,2-bis(-methoxycarbonyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]-indole with lithium diisopropylamide and [C-11]CH3I. After hydrolysis with HI and HPLC purification, the title compound was isolated with a radiochemical yield of 36% (EOB corrected) within 22 min; e.e. was shown > 97% (n = 20); specific activity was ranging between 0.8 and 1.2 Ci (30-45 GBq)/mu mol EOB.

引用

页码：651 / 653

页数：3

共 7 条

[1] ENANTIOSPECIFIC SYNTHESIS WITH AMINO-ACIDS .1. TRYPTOPHAN AS A CHIRON FOR THE SYNTHESIS OF ALPHA-SUBSTITUTED TRYPTOPHAN DERIVATIVES [J].