ENHANCEMENT OF DISSOLUTION RATE BY INCORPORATION INTO A WATER INSOLUBLE POLYMER, POLYCAPROLACTONE

被引：7

作者：

CHANG, RK ^{[1
]}

PRICE, JC ^{[1
]}

WHITWORTH, CW ^{[1
]}

机构：

[1] UNIV GEORGIA, COLL PHARM, ATHENS, GA 30602 USA

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1987年 / 13卷 / 02期

关键词：

D O I：

10.3109/03639048709040170

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

This report concerns the use of water insoluble polymer, polycaprolactone, as a carrier to enhance the dissolution rate of two drugs, chlorpromazine and progesterone. Polycaprolactone microspheres containing these drugs were prepared by an emulsion-solvent evaporation technique and dissolution characteristics were compared to pure drug. Dissolution studies revealed that both chlorpromazine-polycaprolactone and progesterone - polycaprolactone microspheres exhibited a faster dissolution rate than the pure drugs. Molecular or colloidal dispersion of drugs in the polycaprolactone microshere matrix and the high permeability of polycaprolactone to the drugs and water are possible reasons for the rapid release properties observed.

引用

页码：249 / 256

页数：8