CEREBROVASCULAR EFFECT OF CALCIUM-ANTAGONISTS

被引：15

作者：

MOREL, N ^{[1
]}

GODFRAIND, T ^{[1
]}

机构：

[1] CATHOLIC UNIV LOUVAIN, PHARMACODYNAM GEN & PHARMACOL LAB, UCL 7350, AVE EMMANUEL MOURNIER, B-1200 BRUSSELS, BELGIUM

来源：

EUROPEAN NEUROLOGY | 1990年 / 30卷

关键词：

Ca-antagonists; Ca[!sup]2+[!/sup] channels; Cerebral microvessels;

D O I：

10.1159/000117185

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Activity of calcium antagonists was assessed in microvessels (internal diameter 5-50 pm) isolated from rat brain. High KCl solution induced an increase of the lanthanum-resistant45Ca influx and a marked reduction in microvessel diameter. Both responses to depolarization were inhibited by the calcium antagonists nimodipine and flunarizine. Binding studies with3H(+)PN200-110 used as a specific ligand of Ca channels revealed the existence of voltage-dependent, stereoselective binding sites for dihydropyridine calcium antagonists. © 1990 S. Karger AG, Basel.

引用

页码：10 / 15

页数：6

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