PHASE-II STUDY OF CARBOPLATIN IFOSFAMIDE IN UNTREATED ADVANCED CERVICAL-CANCER

被引：16

作者：

KUHNLE, H

MEERPOHL, HG

EIERMANN, W

ROBEN, S

LENAZ, L

ACHTERRATH, W

机构：

[1] UNIV FREIBURG,FRAUENKLIN,HUGSTETTER STR,W-7800 FREIBURG,GERMANY

[2] UNIV HANOVER,FRAUENKLIN,W-3000 HANOVER,GERMANY

[3] UNIV MUNICH,KLINIKUM GROSSHADERN,FRAUENKLIN,W-8000 MUNICH 70,GERMANY

[4] UNIV GOTTINGEN,FRAUENKLIN,W-3400 GOTTINGEN,GERMANY

来源：

CANCER CHEMOTHERAPY AND PHARMACOLOGY | 1990年 / 26卷

关键词：

D O I：

10.1007/BF00685414

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A total of 32 patients with advanced squamous-cell carcinoma of the cervix were treated with 300 mg/m2 i. v. carboplatin and 5 g/m2 ifosfamide as a 24-h i. v. infusion, both given on day 1 every 4 weeks. In all, 3 (9%) complete responses (CRs) and 19 (59%) objective responses (CR+PR) were achieved in 32 patients. Myelosuppression with leukopenia and/or thrombocytopenia of WHO grade 4 in 28% and 13% of patients, respectively, was the main toxicity. The results of our study suggest that carboplatin/ifosfamide is active as neoadjuvant treatment in advanced cervical cancer. © 1990 Springer-Verlag.

引用

页码：S33 / S35

页数：3

共 15 条

[1] RANDOMIZED TRIAL OF 3 CISPLATIN DOSE SCHEDULES IN SQUAMOUS-CELL CARCINOMA OF THE CERVIX - A GYNECOLOGIC ONCOLOGY GROUP-STUDY [J].

BONOMI, P ;

BLESSING, JA ;

STEHMAN, FB ;

DISAIA, PJ ;

WALTON, L ;

MAJOR, FJ .

JOURNAL OF CLINICAL ONCOLOGY, 1985, 3 (08) :1079-1085

[2] COMBINATION BLEOMYCIN, IFOSFAMIDE, AND CISPLATIN CHEMOTHERAPY IN CERVICAL-CANCER [J].

BUXTON, EJ ;

MEANWELL, CA ;

HILTON, C ;

MOULD, JJ ;

SPOONER, D ;

CHETIYAWARDANA, A ;

LATIEF, T ;

PATERSON, M ;

REDMAN, CW ;

LUESLEY, DM ;

BLACKLEDGE, GR .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1989, 81 (05) :359-361

[3]

COLEMAN RE, 1988, BRIT J CANCER, V58, P273

[4]

COLEMAN RE, 1986, CANCER CHEMOTH PHARM, V18, P280

[5]

DINH TV, 1989, P AM SOC SOC CLIN ON, V8, P158

[6]

FORASTIERE AA, 1984, GYNECOLOGIC CANCER, P93

[7]

LIRAPUERTO V, 1989, P AM SOC CLIN ONCOL, V8, pA622

[8]

MCGUIRE WP, 1988, P AM SOC CLIN ONCOL, V7, pA521

[9]

MEANWELL CA, 1986, CANCER TREAT REP, V70, P727

[10]

MILLER AB, 1981, CANCER, V47, P207, DOI 10.1002/1097-0142(19810101)47:1<207::AID-CNCR2820470134>3.0.CO

← 1 2 →