OVERVIEW OF IMMUNOLOGICAL STUDIES ON A-BOMB SURVIVORS

被引：5

作者：

AKIYAMA, M

KUSUNOKI, Y

KYOIZUMI, S

机构：

[1] Radiation Effects Research Foundation, Hiroshima 732, 5–2 Hijiyama Park, Minami-ku

来源：

JOURNAL OF RADIATION RESEARCH | 1991年 / 32卷

关键词：

IMMUNE RESPONSES PHA; MLR; LYMPHOCYTE SUBSETS;

D O I：

10.1269/jrr.32.SUPPLEMENT_301

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Among the peripheral blood lymphocytes, T-cells and B-cells significantly decreased in number with age. Radiation exposure resulted in further significant decrease of T-cell count (but not B cells) in the elderly. T-cell response to PHA and allo-antigens also decreased with dose in the elderly group. In contrast, NK cell number and function increased with age while a significant dose effect was not observed.

引用

收藏

页码：301 / 309

页数：9

相关论文

共 38 条

[1] POSTNATAL EXPANSION OF THE NATURAL-KILLER AND KILLER CELL-POPULATION IN HUMANS IDENTIFIED BY THE MONOCLONAL HNK-1 ANTIBODY [J].

ABO, T ;

COOPER, MD ;

BALCH, CM .

JOURNAL OF EXPERIMENTAL MEDICINE, 1982, 155 (01) :321-326

[2] PERIPHERAL LYMPHOCYTE-RESPONSE TO PHA AND T-CELL POPULATION AMONG ATOMIC-BOMB SURVIVORS [J].

AKIYAMA, M ;

YAMAKIDO, M ;

KOBUKE, K ;

DOCK, DS ;

HAMILTON, HB ;

AWA, AA ;

KATO, H .

RADIATION RESEARCH, 1983, 93 (03) :572-580

[3] AGE AND DOSE RELATED ALTERATION OF INVITRO MIXED LYMPHOCYTE CULTURE RESPONSE OF BLOOD-LYMPHOCYTES FROM A-BOMB SURVIVORS [J].

AKIYAMA, M ;

ZHOU, OL ;

KUSUNOKI, Y ;

KYOIZUMI, S ;

KOHNO, N ;

AKIBA, S ;

DELONGCHAMP, RR .

RADIATION RESEARCH, 1989, 117 (01) :26-34

[4] REGULATORY INTERACTIONS BETWEEN MEMBERS OF THE IMMUNOGLOBULIN SUPERFAMILY [J].

ANDERSON, P ;

MORIMOTO, C ;

BREITMEYER, JB ;

SCHLOSSMAN, SF .

IMMUNOLOGY TODAY, 1988, 9 (7-8) :199-203

[5] IMMUNOLOGICAL RESPONSES OF AGING JAPANESE A-BOMB SURVIVORS [J].

BLOOM, ET ;

AKIYAMA, M ;

KORN, EL ;

KUSUNOKI, Y ;

MAKINODAN, T .

RADIATION RESEARCH, 1988, 116 (02) :343-355

[6] HUMAN-LYMPHOCYTES MAKING RHEUMATOID-FACTOR AND ANTIBODY TO SSDNA BELONG TO LEU-1+ B-CELL SUBSET [J].

CASALI, P ;

BURASTERO, SE ;

NAKAMURA, M ;

INGHIRAMI, G ;

NOTKINS, AL .

SCIENCE, 1987, 236 (4797) :77-81

[7]

FALCAO RP, 1987, DIAGN CLIN IMMUNOL, V5, P205

[8]

FINCH SC, 1979, RERF TR2279

[9]

FUJIWARA S, 1987, RERF RP287 AD HLTH S

[10] INCREASED SOMATIC-CELL MUTANT FREQUENCY IN ATOMIC-BOMB SURVIVORS [J].

HAKODA, M ;

AKIYAMA, M ;

KYOIZUMI, S ;

AWA, AA ;

YAMAKIDO, M ;

OTAKE, M .

MUTATION RESEARCH, 1988, 201 (01) :39-48

← 1 2 3 4 →