PHOSPHOINOSITIDE HYDROLYSIS MEDIATED BY H1 RECEPTORS IN AUTOIMMUNE MYOCARDITIS MICE

被引：3

作者：

GOREN, N ^{[1
]}

LEIROS, CP ^{[1
]}

STERINBORDA, L ^{[1
]}

BORDA, ES ^{[1
]}

机构：

[1] CONSEJO NACL INVEST CIENT & TECN,CEFYBO,SERRANO 665,RA-1414 BUENOS AIRES AIRE,ARGENTINA

来源：

MEDIATORS OF INFLAMMATION | 1993年 / 2卷 / 04期

关键词：

AUTOIMMUNITY; BINDING ASSAY; H1; RECEPTORS; HISTAMINE; MYOCARDITIS; PHOSPHOINOSITIDE TURNOVER;

D O I：

10.1155/S0962935193000444

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

STIMULATION of phosphoinositide hydrolysis in myocardium from autoimmune myocarditis mice by ThEA and histamine was assayed. Myocardium from autoimmune heart, but not the normal forms, specifically increased phosphoinositide turnover in the presence of histaminergic agonists. This increment was blocked by a specific H1 antagonist mepyramine and to the same extent by the phospholipase C inhibitor NCDC. By using a binding assay Hl histaminergic receptors were detected in autoimmune heart membrane preparations, but this was not observed in normal heart. These data suggest that autoimmune myocardium expressed a functional H1 receptor that could involve a distinctive mechanism operating in the disease.

引用

页码：317 / 322

页数：6

共 24 条

[1]

BEAVEN MA, 1982, PHARM HISTAMINE RECE, P103

[2] LITHIUM AMPLIFIES AGONIST-DEPENDENT PHOSPHATIDYLINOSITOL RESPONSES IN BRAIN AND SALIVARY-GLANDS [J].

BERRIDGE, MJ ;

DOWNES, CP ;

HANLEY, MR .

BIOCHEMICAL JOURNAL, 1982, 206 (03) :587-595

[3] INOSITOL TRISPHOSPHATE, A NOVEL 2ND MESSENGER IN CELLULAR SIGNAL TRANSDUCTION [J].

BERRIDGE, MJ ;

IRVINE, RF .

NATURE, 1984, 312 (5992) :315-321

[4]

CHANG RSL, 1979, J PHARMACOL EXP THER, V209, P437

[5] HISTAMINE H1-RECEPTORS IN BRAIN LABELED WITH MEPYRAMINE-H-3 [J].

CHANG, RSL ;

TRAN, VT ;

SNYDER, SH .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1978, 48 (04) :463-464

[6] EXPERIMENTAL MYOCARDITIS INDUCED IN SWISS MICE BY HOMOLOGOUS HEART IMMUNIZATION RESEMBLES CHRONIC EXPERIMENTAL CHAGAS HEART-DISEASE [J].

COSSIO, PM ;

BUSTUOABAD, O ;

PATERNO, E ;

IOTTI, R ;

CASANOVA, MB ;

PODESTA, MR ;

BOLOMO, N ;

ARANA, RM ;

DEPASQUALINI, CD .

CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY, 1984, 33 (02) :165-175

[7]

GORELIK G, 1992, J LIPID MEDIATOR, V5, P249

[8]

GOREN N, 1991, MEDICINA, V51, P421

[9]

HATTORI Y, 1989, N-S ARCH PHARMACOL, V340, P196

[10]

HILL SJ, 1990, PHARMACOL REV, V42, P45

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