TREATMENT OF CHRONIC HEPATITIS-B WITH INTERFERON-ALFA-2B

被引:22
作者
MULLER, R
BAUMGARTEN, R
MARKUS, R
SCHULZ, M
WITTENBERG, H
HINTSCHEKILGER, B
FENGLER, JD
VONWUSSOW, P
MEISEL, H
KLEIN, H
MALMUS, K
SCHMIDT, FW
机构
[1] STADT KRANKENHAUS BERLIN PRENZLAUER BERG,INFEKT KLIN,BERLIN,GERMANY
[2] HANOVER MED SCH,ZENTRUM INNERE MED & DERMATOL,KLIN IMMUNOL ABT,W-3000 HANNOVER 61,GERMANY
[3] HUMBOLDT UNIV,BEREICH MED CHARITE,INST MED VIROL,O-1040 BERLIN,GERMANY
关键词
D O I
10.1016/0168-8278(90)90181-P
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
A total of 58 patients with histologically confirmed chronic viral hepatitis B and presence of hepatitis B surface antigen and hepatitis B virus DNA (HBV DNA) in the serum were randomized in a prospectively controlled trial. Thirty patients were treated with 3 megaunits of recombinant interferon alfa-2b (INTRON A, R Schering-Plough, Essex Corporation) subcutaneously thrice weekly for 4 months. Twenty-eight controls received no treatment. The post-treatment follow-up period consisted of 6 months. Twenty-eight treated patients and 27 controls completed the protocol. One female patient of the treatment group showed a complete response, and eight other treated patients (32%) showed a partial response to therapy. Three patients in the control group (11%) lost hepatitis B e antigen and HBV DNA spontaneously. This finding is statistically significant (p < 0.05). The elimination of hepatitis B virus markers from the serum was associated with a normalization of aminotransferase activities in the serum. Reactivation of hepatitis was not observed after seroconversion.
引用
收藏
页码:S137 / S140
页数:4
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