PROCHIRAL SELECTIVITY AND INTRAMOLECULAR ISOTOPE EFFECTS IN THE CYTOCHROME-P-450 CATALYZED OMEGA-HYDROXYLATION OF CUMENE

被引：20

作者：

SUGIYAMA, K ^{[1
]}

TRAGER, WF ^{[1
]}

机构：

[1] UNIV WASHINGTON,SCH PHARM,DEPT MED CHEM,SEATTLE,WA 98195

来源：

BIOCHEMISTRY | 1986年 / 25卷 / 23期

关键词：

D O I：

10.1021/bi00371a015

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：7336 / 7343

页数：8

共 14 条

[1]

Allen C. F. H., 1943, ORG SYNTH, V3, P377

[2]

BERGSON G, 1977, CHEM SCRIPTA, V2, P25

[3]

BUSH ED, 1985, J MED CHEM, V28, P922

[4] STUDIES IN STEREOCHEMISTRY .5. PHENONIUM SULFONATE ION-PAIRS AS INTERMEDIATES IN THE INTRAMOLECULAR REARRANGEMENTS AND SOLVOLYSIS REACTIONS THAT OCCUR IN THE 3-PHENYL-2-BUTANOL SYSTEM [J].

CRAM, DJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1952, 74 (09) :2129-2137

[5] STEREOCHEMISTRY AND DEUTERIUM-ISOTOPE EFFECTS IN CAMPHOR HYDROXYLATION BY THE CYTOCHROME P450CAM MONOXYGENASE SYSTEM [J].

GELB, MH ;

HEIMBROOK, DC ;

MALKONEN, P ;

SLIGAR, SG .

BIOCHEMISTRY, 1982, 21 (02) :370-377

[6] ALIPHATIC HYDROXYLATION BY HIGHLY PURIFIED LIVER MICROSOMAL CYTOCHROME-P-450 - EVIDENCE FOR A CARBON RADICAL INTERMEDIATE [J].

GROVES, JT ;

MCCLUSKY, GA ;

WHITE, RE ;

COON, MJ .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1978, 81 (01) :154-160

[7] INTRAMOLECULAR DETERMINATION OF PRIMARY KINETIC ISOTOPE EFFECTS IN HYDROXYLATIONS CATALYZED BY CYTOCHROME-P-450 [J].

HJELMELAND, LM ;

ARONOW, L ;

TRUDELL, JR .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1977, 76 (02) :541-549

[8]

LU AYH, 1980, PHARMACOL REV, V31, P277

[9]

MIWA GT, 1980, J BIOL CHEM, V255, P6049

[10] STEADY-STATE ANALYSIS OF KINETIC ISOTOPE-EFFECTS IN ENZYMIC REACTIONS [J].

NORTHROP, DB .

BIOCHEMISTRY, 1975, 14 (12) :2644-2651

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