MANAGEMENT OF PATIENTS AND SIDE-EFFECTS DURING CYCLOSPORINE THERAPY FOR CUTANEOUS DISORDERS

被引:54
作者
FRADIN, MS [1 ]
ELLIS, CN [1 ]
VOORHEES, JJ [1 ]
机构
[1] UNIV MICHIGAN,MED CTR,DEPT DERMATOL,DERMATOPHARMACOL UNIT,ROOM 1910,TAUBMAN CTR,ANN ARBOR,MI 48109
关键词
D O I
10.1016/0190-9622(90)70353-J
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Cyclosporine has been used in the experimental treatment of multiple inflammatory diseases of presumed autoimmune origin, including insulin-dependent diabetes mellitus, uveitis, rheumatoid arthritis, inflammatory bowel diseases, Graves' disease, and myasthenia gravis. In dermatology, the drug has been used successfully as primary therapy for psoriasis and psoriatic arthritis, alopecia areata, pyoderma gangrenosum, Behçet's disease, atopic dermatitis, and lichen planus. At a dose of 3 to 5 mg/kg per day, cyclosporine is well tolerated by most patients, However, because of concerns about its potential short- and long-term side effects, patients who use this drug require close monitoring. This review discusses appropriate clinical and laboratory evaluations, common and unusual side effects and their management, drugs that might alter the pharmacokinetics of cyclosporine metabolism, and criteria for dosage adjustments. © 1990, American Academy of Dermatology, Inc.. All rights reserved.
引用
收藏
页码:1265 / 1275
页数:11
相关论文
共 126 条
[1]   PHARMACODYNAMICS OF CYCLOSPORINE-KETOCONAZOLE INTERACTION IN MICE - COMBINED THERAPY POTENTIATES CYCLOSPORINE IMMUNOSUPPRESSION AND TOXICITY [J].
ANDERSON, JE ;
MORRIS, RE ;
BLASCHKE, TF .
TRANSPLANTATION, 1987, 43 (04) :529-533
[2]  
ATKINSON K, 1983, TRANSPLANT P, V15, P2761
[3]  
BACH JF, 1989, TRANSPLANT P, V21, P97
[4]   EFFECTS OF CYCLOSPORINE THERAPY ON PLASMA-LIPOPROTEIN LEVELS [J].
BALLANTYNE, CM ;
PODET, EJ ;
PATSCH, WP ;
HARATI, Y ;
APPEL, V ;
GOTTO, AM ;
YOUNG, JB .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1989, 262 (01) :53-56
[5]  
BANTLE JP, 1990, J LAB CLIN MED, V115, P233
[6]  
BARON R, 1984, BONE MINERAL RES ANN, V2, P175
[7]  
BARTHELEMY H, 1986, TRANSPLANT P, V18, P913
[8]  
BENDTZEN K, 1984, LANCET, V1, P792
[9]  
BENEZRA D, 1988, TRANSPLANT P, V20, P136
[10]   CYCLOSPORINE-ASSOCIATED HYPERTENSION [J].
BENNETT, WM ;
PORTER, GA .
AMERICAN JOURNAL OF MEDICINE, 1988, 85 (02) :131-133